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Impact de l’âge et du sexe sur les aspects cliniques et épidémiologiques du psoriasis de l’enfant. Données d’une étude transversale multicentrique française

J. Bonigen 1 A. Phan 2 S. Hadj-Rabia 3, 4, 5, 6 F Boralevi 7 A.C. Bursztejn 8 C. Bodemer 3, 4 M. Ferneiny 3, 4 A.L. Souillet 2 C. Chiaverini 9 E. Bourrat 10 J. Miquel 11, 12 P. Vabres 13 S. Barbarot 14 D. Bessis 15, 16 C. Eschard 17 J. Mazereeuw-Hautier 18 M. Piram 19, 20 P. Plantin 21 C. Abasq 22 A. Lasek-Duriez 23 A. Maruani 24 A. Beauchet 25 E. Mahé 1 Groupe de Recherche de La Société Française de Dermatologie Pédiatrique
1 Centre Hospitalier Victor Dupouy
2 HFME - Hôpital Femme Mère Enfant [CHU - HCL]
3 Service de dermatologie [CHU Necker]
4 UPD5 - Université Paris Descartes - Paris 5
5 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
6 USPC - Université Sorbonne Paris Cité
7 Hôpital Pellegrin
8 Service de Dermatologie et Allergologie [CHRU Nancy]
9 Service de Dermatologie [Nice]
10 AP-HP Hôpital universitaire Robert-Debré [Paris]
11 Service de Dermatologie [Rennes] = Dermatology [Rennes]
12 CHR La réunion
13 Service de Dermatologie (CHU de Dijon)
14 Service de dermatologie [Nantes]
15 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
16 Pathogénèse et contrôle des infections chroniques (PCCI)
17 Service de dermatologie (CHU de Reims)
18 Service de dermatologie (CHU de Toulouse)
19 Service de Rhumatologie [CHU Bicêtre]
20 UP11 - Université Paris-Sud - Paris 11
21 Centre hospitalier de Cornouaille
22 Dermato - BREST - Service de dermatologie
23 Hôpital Saint-Vincent de Paul
24 Service de dermatologie (CHRU de Tours)
25 Hôpital Ambroise Paré [AP-HP]
Abstract : BACKGROUND The prevalence of childhood psoriasis is estimated at between 0.4% and 0.7%. Clinical aspects of the diseases depend on age. The aim of this study was to investigate the clinical aspects of psoriasis according to age and sex. PATIENTS AND METHODS A cross-sectional, multicentre study of children with psoriasis was performed by investigators belonging to the Research Group of the French Society of Paediatric Dermatology. The study was conducted from April 2012 to March 2013. Inclusion criteria were age less than 18 years and clinical diagnosis of psoriasis. The children were classified into 3 groups by age: infants: <2 years; children: ≥2 years and <13 years; adolescents≥13 years. The information collected included demographic data, clinical, epidemiological, and therapeutic aspects of the psoriasis, as well as analysis of comorbidities. RESULTS Three hundred and thirteen children were included: 27 (8.6%) infants, 207 (66.1%) children, and 79 (25.2%) adolescents. Plaque psoriasis was the most frequent clinical type of psoriasis seen in children and adolescents (>41%), but it accounted for only 25.9% of psoriasis of infants (P<0.0001). Napkin psoriasis (37.0%) and inverse psoriasis (22.2%) were the most common forms of psoriasis seen in infants and were described significantly more frequently in this group than in the two other groups (P<0.003). Nail involvement was more common in adolescents (37.2%, P=0.03) and children (32.9%) than in infants (14.8%) and affected boys more than girls (43.6% vs 22.0%, P<0.0001). Girls presented scalp psoriasis more frequently (17.7% vs 8.7%, P=0.02). Local vitamin-D treatment and systemic therapies were used more frequently in children and adolescents than in infants. There was no significant difference for treatment use, including for acitretin, according to gender. DISCUSSION Plaque psoriasis was the most common clinical type of psoriasis in children but affected less than 50% of the children. Age had a significant impact on extra-cutaneous skin disorders and on treatment used, while sex had little incidence. The frequency of comorbidities was not affected by age. CONCLUSION Childhood psoriasis thus presents specific characteristics dependent on the age of the child. The results of studies exclusively dealing with adults cannot be extrapolated to children.
Mots-clés : Nourrisson Psoriasis Child Enfant Infant Adolescent
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https://hal.umontpellier.fr/hal-01985254
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Soumis le : jeudi 17 janvier 2019 - 17:36:15
Dernière modification le : mardi 11 janvier 2022 - 10:35:22

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UNIV-MONTPELLIER | HCL | UNIV-PARIS5 | BS | UNIV-NANTES | USPC | UNIV-PARIS | PCCI

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J. Bonigen, A. Phan, S. Hadj-Rabia, F Boralevi, A.C. Bursztejn, et al.. Impact de l’âge et du sexe sur les aspects cliniques et épidémiologiques du psoriasis de l’enfant. Données d’une étude transversale multicentrique française. Annales de Dermatologie et de Vénéréologie, Elsevier Masson, 2016, 143 (5), pp.354-363. ⟨10.1016/j.annder.2016.02.006⟩. ⟨hal-01985254⟩

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