[Circulating nucleic acids and infertility].
Les acides nucléiques circulants et infertilité
Résumé
Circulating nucleic acids (cell-free DNA and microRNAs) have for particularity to be easily detectable in the biological fluids of the body. Therefore, they constitute biomarkers of interest in female and male infertility care. Indeed, in female, they can be used to detect ovarian reserve disorders (polycystic ovary syndrome and low functional ovarian reserve) as well as to assess follicular microenvironment quality. Moreover, in men, their expression levels can vary in case of spermatogenesis abnormalities. Finally, circulating nucleic acids have also the ability to predict successfully the quality of in vitro embryo development. Their multiple contributions during assisted reproductive technology (ART) make of them biomarkers of interest, for the development of new diagnostic and/or prognostic tests, applied to our specialty. Circulating nucleic acids would so offer the possibility of personalized medical care for infertile couples in ART.
Mots clés
ADN libre
Acides nucléiques circulants
Assistance médicale à la procréation
Assisted reproductive technology
Cell-free DNA
Circulating nucleic acids
Embryo quality
Follicular micro-environment
Infertilité masculine
Male infertility
Microenvironnement folliculaire
Ovarian reserve
Qualité embryonnaire
Réserve ovarienne
microARNs
microRNAs