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Article Dans Une Revue Current Pharmaceutical Design Année : 2014

Systems medicine approaches for the definition of complex phenotypes in chronic diseases and ageing. From concept to implementation and policies.

Jean Bousquet (1, 2) , Christian Jorgensen (1, 2, 3) , Michel Dauzat (2, 4, 5) , Alfredo Cesario , Thierry Camuzat (2) , Rodolphe Bourret (1, 2) , Nicolas Best (2, 4) , Josep M. Anto , Frédéric Abécassis (2) , Pierre Aubas (1, 2) , Antoine Avignon (1, 2, 6) , Mélanie Badin (2, 4) , Anna Bedbrook , Hubert Blain (1, 2) , Arnaud Bourdin (1, 2, 6) , Jacques Bringer (1, 2) , William Camu (1, 2) , Guilhaume Cayla (2, 4) , David Costa (2, 4) , Philippe Courtet (1, 2) , Jean-Paul Cristol (1, 2, 6) , Pascal Demoly (1, 2) , Jean-Emmanuel de La Coussaye (2, 4, 5) , Pierre Fesler (1, 2, 6) , Fares Gouzi (1, 2, 6) , Jean-Christophe Gris (2, 4, 5) , Bernard Guillot (1, 2) , Maurice Hayot (1, 2, 6) , Claude Jeandel (1, 2) , Olivier Jonquet (1, 2) , Laurent Journot (2, 7) , Sylvain Lehmann (1) , Gwenaelle Mathieu (2, 4) , Jacques Morel (1, 2) , Gregory Ninot (2) , Jacques Pélissier (2, 4) , Marie-Christine Picot (1, 2) , Francois Radier-Pontal (2) , Jm Robine (2, 8) , Michel Rodier (2, 4) , François Roubille (2, 1, 6) , Ariane Sultan (1, 2, 6) , Anne Wojtusciszyn (1, 2) , Charles Auffray (9) , Rudi Balling , Cristina Bárbara , Anne Cambon-Thomsen (10) , Niels Chavannes , Alexander Chuchalin , George Crooks , Antoni Dedeu , Leonardo Fabbri , Judith Garcia-Aymerich , Jawad Hajjam (11) , Elisabete Melo Gomes , Susana Palkonen (12) , François Piette (13) , Christophe M. Pison (14, 15) , David Price , Boleslaw Samolinski , Holger J. Schünemann , Peter Sterk , Panayiotis Yiallouros , Josep Roca , Philippe van de Perre (1, 2) , Jacques Mercier (1, 2, 6)
Alfredo Cesario
  • Fonction : Auteur
Josep M. Anto
  • Fonction : Auteur
Anna Bedbrook
Rudi Balling
  • Fonction : Auteur
Cristina Bárbara
  • Fonction : Auteur
Niels Chavannes
  • Fonction : Auteur
Alexander Chuchalin
  • Fonction : Auteur
George Crooks
  • Fonction : Auteur
Antoni Dedeu
  • Fonction : Auteur
Leonardo Fabbri
  • Fonction : Auteur
Judith Garcia-Aymerich
Elisabete Melo Gomes
  • Fonction : Auteur
David Price
  • Fonction : Auteur
Boleslaw Samolinski
  • Fonction : Auteur
Holger J. Schünemann
  • Fonction : Auteur
Peter Sterk
  • Fonction : Auteur
Panayiotis Yiallouros
  • Fonction : Auteur
Josep Roca
  • Fonction : Auteur

Résumé

Chronic diseases are diseases of long duration and slow progression. Major NCDs (cardiovascular diseases, cancer, chronic respiratory diseases, diabetes, rheumatologic diseases and mental health) represent the predominant health problem of the Century. The prevention and control of NCDs are the priority of the World Health Organization 2008 Action Plan, the United Nations 2010 Resolution and the European Union 2010 Council. The novel trend for the management of NCDs is evolving towards integrative, holistic approaches. NCDs are intertwined with ageing. The European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) has prioritised NCDs. To tackle them in their totality in order to reduce their burden and societal impact, it is proposed that NCDs should be considered as a single expression of disease with different risk factors and entities. An innovative integrated health system built around systems medicine and strategic partnerships is proposed to combat NCDs. It includes (i) understanding the social, economic, environmental, genetic determinants, as well as the molecular and cellular mechanisms underlying NCDs; (ii) primary care and practice-based interprofessional collaboration; (iii) carefully phenotyped patients; (iv) development of unbiased and accurate biomarkers for comorbidities, severity and follow up of patients; (v) socio-economic science; (vi) development of guidelines; (vii) training; and (viii) policy decisions. The results could be applicable to all countries and adapted to local needs, economy and health systems. This paper reviews the complexity of NCDs intertwined with ageing. It gives an overview of the problem and proposes two practical examples of systems medicine (MeDALL) applied to allergy and to NCD co-morbidities (MACVIA-LR, Reference Site of the European Innovation Partnership on Active and Healthy Ageing).

Domaines

Pharmacologie

Dates et versions

hal-01952751 , version 1 (12-12-2018)

Identifiants

Citer

Jean Bousquet, Christian Jorgensen, Michel Dauzat, Alfredo Cesario, Thierry Camuzat, et al.. Systems medicine approaches for the definition of complex phenotypes in chronic diseases and ageing. From concept to implementation and policies.. Current Pharmaceutical Design, 2014, 20 (38), pp.5928-44. ⟨10.2174/1381612820666140314115505⟩. ⟨hal-01952751⟩
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