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Reversal of a rocuronium-induced grade IV anaphylaxis via early injection of a large dose of sugammadex

Abstract : AIM: To report rapid recovery from grade IV rocuronium-induced anaphylaxis with a large dose of sugammadex administered early after the onset of symptoms. CLINICAL FEATURES: A 22-yr-old female without relevant medical history developed an anaphylactic reaction within three minutes of rocuronium injection at induction of anesthesia for a routine cholecystectomy. During the first six minutes, she was unresponsive to usual treatment and her condition evolved to a grade IV anaphylaxis reaction despite a cumulated dose of epinephrine 0.7 mg. Sugammadex 14 mg·kg(-1), injected six minutes after rocuronium, resulted in total resolution of all manifestations of anaphylaxis within three minutes. The patient was discharged from hospital the next day. Allergy investigations confirmed rocuronium as the cause of anaphylaxis. CONCLUSION: Very early administration of a large dose of sugammadex may be an effective treatment for rocuronium-induced anaphylaxis.
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https://hal.umontpellier.fr/hal-01945974
Contributeur : Anthony Herrada <>
Soumis le : mercredi 5 décembre 2018 - 16:37:29
Dernière modification le : vendredi 12 juin 2020 - 16:58:20

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Benjamin Conte, Lana Zoric, Gerard Bonada, Bertrand Debaene, Jacques Ripart. Reversal of a rocuronium-induced grade IV anaphylaxis via early injection of a large dose of sugammadex. Canadian Journal of Anesthesia / Journal canadien d'anesthésie, Springer Verlag, 2014, 61 (6), pp.558-562. ⟨10.1007/s12630-014-0148-3⟩. ⟨hal-01945974⟩

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