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Gender differences in cancer patients with acute venous thromboembolism

Abstract : BACKGROUND: The outcome of cancer patients with acute venous thromboembolism (VTE) may differ according to gender. METHODS: We used the RIETE database to compare the rate of VTE (pulmonary embolism [PE] or deep vein thrombosis [DVT]) recurrences), major bleeding and mortality during the course of anticoagulation, according to gender. RESULTS: As of August 2014, 11,055 patients with active cancer were enrolled in RIETE, of whom 5,104 (46%) were women. During the course of anticoagulation (mean: 142 days), 505 patients developed recurrent VTE, 429 bled and 2730 died. Compared with men, women had a significantly lower rate of fatal bleeding (risk ratio [RR]: 0.69; 95% CI: 0.47-0.99) and death (RR: 0.90; 95% CI: 0.83-0.97), and a non-significantly lower rate of PE recurrences (RR 0.83; 95% CI: 0.65-1.06) and major bleeding (RR: 0.89; 95% CI: 0.74-1.08). CONCLUSIONS: During the course of anticoagulation, cancer women with VTE had a better outcome than men.
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https://hal.umontpellier.fr/hal-01944516
Contributeur : Anthony Herrada <>
Soumis le : mardi 4 décembre 2018 - 16:47:48
Dernière modification le : vendredi 15 mai 2020 - 12:22:07

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Francisco Martín-Martos, Javier Trujillo-Santos, Manuel Barrón, Jerónimo Vela, Pablo Javier Marchena, et al.. Gender differences in cancer patients with acute venous thromboembolism. Thrombosis Research, Elsevier, 2015, 135, pp.S12-S15. ⟨10.1016/S0049-3848(15)50433-7⟩. ⟨hal-01944516⟩

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