Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

The Strange Lifestyle of Multipartite Viruses

Abstract : Multipartite viruses have one of the most puzzling genetic organizations found in living organisms. These viruses have several genome segments, each containing only a part of the genetic information, and each individually encapsidated into a separate virus particle. While countless studies on molecular and cellular mechanisms of the infection cycle of multipartite viruses are available, just as for other virus types, very seldom is their lifestyle questioned at the viral system level. Moreover, the rare available “system” studies are purely theoretical, and their predictions on the putative benefit/cost balance of this peculiar genetic organization have not received experimental support. In light of ongoing progresses in general virology, we here challenge the current hypotheses explaining the evolutionary success of multipartite viruses and emphasize their shortcomings. We also discuss alternative ideas and research avenues to be explored in the future in order to solve the long-standing mystery of how viral systems composed of interdependent but physically separated information units can actually be functional.
Type de document :
Article dans une revue
Liste complète des métadonnées

Littérature citée [86 références]  Voir  Masquer  Télécharger

https://hal.umontpellier.fr/hal-01942651
Contributeur : HAL Mivegec Connectez-vous pour contacter le contributeur
Soumis le : lundi 3 décembre 2018 - 13:34:33
Dernière modification le : vendredi 5 août 2022 - 10:58:07
Archivage à long terme le : : lundi 4 mars 2019 - 14:13:20

Fichier

journal.ppat.1005819.PDF
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Citation

Anne Sicard, Yannis Michalakis, Serafin Gutierrez, Stéphane Blanc. The Strange Lifestyle of Multipartite Viruses. PLoS Pathogens, Public Library of Science, 2016, 12 (11), pp.e1005819. ⟨10.1371/journal.ppat.1005819⟩. ⟨hal-01942651⟩

Partager

Métriques

Consultations de la notice

155

Téléchargements de fichiers

75