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Article Dans Une Revue Diabetologia Année : 2014

Differential regulation of mouse pancreatic islet insulin secretion and Smad proteins by activin ligands

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Haiya Wu
  • Fonction : Auteur
Patricia Marmol
  • Fonction : Auteur
Tingqing Guo
  • Fonction : Auteur
Annalena Moliner
  • Fonction : Auteur
Shao-Nian Yang
  • Fonction : Auteur
Per-Olof Berggren
  • Fonction : Auteur
  • PersonId : 1004326

Résumé

Glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells is regulated by paracrine factors, the identity and mechanisms of action of which are incompletely understood. Activins are expressed in pancreatic islets and have been implicated in the regulation of GSIS. Activins A and B signal through a common set of intracellular components, but it is unclear whether they display similar or distinct functions in glucose homeostasis.

Dates et versions

hal-01904736 , version 1 (25-10-2018)

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Haiya Wu, Karima Mezghenna, Patricia Marmol, Tingqing Guo, Annalena Moliner, et al.. Differential regulation of mouse pancreatic islet insulin secretion and Smad proteins by activin ligands. Diabetologia, 2014, 57 (1), pp.148 - 156. ⟨10.1007/s00125-013-3079-6⟩. ⟨hal-01904736⟩
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