Counteracting neuronal nitric oxide synthase proteasomal degradation improves glucose transport in insulin-resistant skeletal muscle from Zucker fa/fa rats - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Diabetologia Année : 2014

Counteracting neuronal nitric oxide synthase proteasomal degradation improves glucose transport in insulin-resistant skeletal muscle from Zucker fa/fa rats

Résumé

Insulin-mediated glucose transport and utilisation are decreased in skeletal muscle from type 2 diabetic and glucose-intolerant individuals because of alterations in insulin receptor signalling, GLUT4 translocation to the plasma membrane and microvascular blood flow. Catalytic activity of the muscle-specific isoform of neuronal nitric oxide synthase (nNOS) also participates in the regulation of glucose transport and appears to be decreased in a relevant animal model of drastic insulin resistance, the obese Zucker fa/fa rat. Our objective was to determine the molecular mechanisms involved in this defect.

Dates et versions

hal-01904731 , version 1 (25-10-2018)

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Karima Mezghenna, Jérémy Leroy, Jacqueline Azay-Milhau, Didier Tousch, Françoise Castex, et al.. Counteracting neuronal nitric oxide synthase proteasomal degradation improves glucose transport in insulin-resistant skeletal muscle from Zucker fa/fa rats. Diabetologia, 2014, 57 (1), pp.177 - 186. ⟨10.1007/s00125-013-3084-9⟩. ⟨hal-01904731⟩
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