Counteracting neuronal nitric oxide synthase proteasomal degradation improves glucose transport in insulin-resistant skeletal muscle from Zucker fa/fa rats

Abstract : Insulin-mediated glucose transport and utilisation are decreased in skeletal muscle from type 2 diabetic and glucose-intolerant individuals because of alterations in insulin receptor signalling, GLUT4 translocation to the plasma membrane and microvascular blood flow. Catalytic activity of the muscle-specific isoform of neuronal nitric oxide synthase (nNOS) also participates in the regulation of glucose transport and appears to be decreased in a relevant animal model of drastic insulin resistance, the obese Zucker fa/fa rat. Our objective was to determine the molecular mechanisms involved in this defect.
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https://hal.umontpellier.fr/hal-01904731
Contributeur : Laurianne Adin <>
Soumis le : jeudi 25 octobre 2018 - 11:39:51
Dernière modification le : mardi 28 mai 2019 - 14:12:03

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Karima Mezghenna, Jérémy Leroy, Jacqueline Azay-Milhau, Didier Tousch, Françoise Castex, et al.. Counteracting neuronal nitric oxide synthase proteasomal degradation improves glucose transport in insulin-resistant skeletal muscle from Zucker fa/fa rats. Diabetologia, Springer Verlag, 2014, 57 (1), pp.177 - 186. ⟨10.1007/s00125-013-3084-9⟩. ⟨hal-01904731⟩

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