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Use of quantitative susceptibility mapping (QSM) in progressive multifocal leukoencephalopathy

Abstract : BACKGROUND: Progressive multifocal leukoencephalopathy (PML) is an opportunistic demyelinating encephalopathy related to JC virus. Its characteristics on conventional brain MRI are well known and are important for the diagnosis. OBJECTIVE: To analyze SWI hypointensities recently described in U-fibers and cortex adjacent to the white matter lesions of PML. METHODS: Prospective study including four patients with an history of definite diagnosis of PML. Clinical data were collected retrospectively. Brain MRI exams were done on a 3T magnet, including FLAIR, T2 GRE sequences and SWI. RESULTS: Four males were included (mean age: 47 years, mean PML duration: 24.2 months). Immunosuppression was related to AIDS (n=2), natalizumab for multiple sclerosis (n=1), B-cell lymphoma treated by chemotherapeutic agents and rituximab (n=1). All patients had SWI hypointensities in cortex and/or U-fibers adjacent to the white matter lesions. QSM always suggested a paramagnetic effect. CONCLUSION: SWI and T2 GRE hypointensities in cortex and U-fibers adjacent to the white matter lesions seem highly prevalent in PML, irrespective of the delay between PML onset and the MRI. QSM data suggest a paramagnetic effect.
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Soumis le : mercredi 3 octobre 2018 - 16:25:15
Dernière modification le : vendredi 15 mai 2020 - 12:22:07




C. Carra-Dallière, Nicolas Menjot de Champfleur, Jeremy Deverdun, Xavier Ayrignac, E. Nerrant, et al.. Use of quantitative susceptibility mapping (QSM) in progressive multifocal leukoencephalopathy. American Journal of Neuroradiology, American Society of Neuroradiology, 2016, 43 (1), pp.6 - 10. ⟨10.1016/j.neurad.2015.08.001⟩. ⟨hal-01887136⟩



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