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Telephone-administered psychotherapy in combination with antidepressant medication for the acute treatment of major depressive disorder

Abstract : BACKGROUND: Telephone-administered psychotherapies (T-P) provided as an adjunct to antidepressant medication may improve response rates in major depressive disorder (MDD). The goal of this study was to compare telephone-administered social rhythm therapy (T-SRT) and telephone-administered intensive clinical management (T-ICM) as adjuncts to antidepressant medication for MDD. A secondary goal was to compare T-P with Treatment as Usual (TAU) as adjunctive treatment to medication for MDD. METHODS: 221 adult out-patients with MDD, currently depressed, were randomly assigned to 8 sessions of weekly T-SRT (n=110) or T-ICM (n=111), administered as an adjunct to agomelatine. Both psychotherapies were administered entirely by telephone, by trained psychologists who were blind to other aspects of treatment. The 221 patients were a posteriori matched with 221 depressed outpatients receiving TAU (controls). The primary outcome measure was the percentage of responders at 8 weeks post-treatment. RESULTS: No significant differences were found between T-SRT and T-ICM. But T-P was associated with higher response rates (65.4% vs 54.8%, p=0.02) and a trend toward higher remission rates (33.2% vs 25.1%; p=0.06) compared to TAU. LIMITATIONS: Short term study. CONCLUSIONS: This study is the first assessing the short-term effects of an add-on, brief, telephone-administered psychotherapy in depressed patients treated with antidepressant medication. Eight sessions of weekly telephone-delivered psychotherapy as an adjunct to antidepressant medication resulted in improved response rates relative to medication alone.
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Soumis le : mercredi 3 octobre 2018 - 15:58:47
Dernière modification le : mercredi 14 octobre 2020 - 04:09:41

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Emmanuelle Corruble, Holly Swartz, Thierry Bottai, Guillaume Vaiva, F. Bayle, et al.. Telephone-administered psychotherapy in combination with antidepressant medication for the acute treatment of major depressive disorder. Journal of Affective Disorders, Elsevier, 2016, 190, pp.6 - 11. ⟨10.1016/j.jad.2015.07.052⟩. ⟨hal-01887099⟩

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