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Reversible growth failure and complete GH deficiency in a 4-year-old girl with very early Hashimoto’s thyroiditis and subsequent hyperplasia of pituitary thyrotroph cells

Abstract : Hashimoto's thyroiditis is a well-known cause of growth retardation in adolescence. It is less frequently seen in children and rarely seen in infants. A 4-year-old girl was referred to our clinic for a second opinion before starting growth hormone (GH) treatment. Linear growth had markedly declined in the past 2 years, with height -3.4 standard deviations. GH deficiency was complete. She had dry, gray-sallow skin and bloated abdomen, but no goiter. The parents reported fatigue and constipation. Hormonal evaluation revealed TSH 629.5 mIU/ml, free T4 0.08 ng/dl, and prolactin 17.2 ng/ml. Bone age was 2 years. Antibodies to thyroglobulin and thyroid peroxidase were positive, suggesting Hashimoto's thyroiditis. Brain magnetic resonance imaging showed anterior pituitary hyperplasia. After 3 years of L-thyroxine therapy, she was symptomless, her height was -0.6 standard deviations, and the TSH level was normal. Brain magnetic resonance imaging showed regression of the pituitary hyperplasia.
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https://hal.umontpellier.fr/hal-01881363
Contributeur : Cécile Nowak <>
Soumis le : mardi 25 septembre 2018 - 17:26:11
Dernière modification le : vendredi 15 mai 2020 - 12:22:06

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Laura Gaspari, Françoise Paris, Nicolas Leboucq, Alain Bonafe, Charles Sultan. Reversible growth failure and complete GH deficiency in a 4-year-old girl with very early Hashimoto’s thyroiditis and subsequent hyperplasia of pituitary thyrotroph cells. European Journal of Pediatrics, Springer Verlag, 2016, 175 (8), pp.1119 - 1122. ⟨10.1007/s00431-016-2698-6⟩. ⟨hal-01881363⟩

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