Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Localized Structural Alterations Underlying a Subset of Unexplained Sudden Cardiac Death

Michel Haïssaguerre 1 Mélèze Hocini 1 Ghassen Cheniti 1 Josselin Duchateau 2 Fréderic Sacher 1 Stéphane Puyo 1 Hubert Cochet 3 Masateru Takigawa 1 Arnaud Denis 1 Ruairidh Martin 1 Nicolas Derval 4 Pierre Bordachar 5 Philippe Ritter 3 Sylvain Ploux 4 Thomas Pambrun 1 Nicolas Klotz 1 Grégoire Massoullié 1 Xavier Pillois 1 Corentin Dallet 1 Jean-Jacques Schott 6 Solena Le Scouarnec 7 Michael Ackerman 8 David Tester 8 Olivier Piot 1 Jean-Luc Pasquié 9, 10 Christophe Leclerc 11 Jean-Sylvain Hermida 12 Estelle Gandjbakhch 13 Philippe Maury 14 Louis Labrousse 1 Ruben Coronel 1 Pierre Jaïs 3 David Benoist 15 Edward J. Vigmond 16 Mark Potse 1, 16, 17 Richard D. Walton 1 Koonlawee Nademanee 18 Olivier Bernus 1 Rémi Dubois 1
Abstract : Background - Sudden cardiac death because of ventricular fibrillation (VF) is commonly unexplained in younger victims. Detailed electrophysiological mapping in such patients has not been reported. Methods - We evaluated 24 patients (29±13 years) who survived idiopathic VF. First, we used multielectrode body surface recordings to identify the drivers maintaining VF. Then, we analyzed electrograms in the driver regions using endocardial and epicardial catheter mapping during sinus rhythm. Established electrogram criteria were used to identify the presence of structural alterations. Results - VF occurred spontaneously in 3 patients and was induced in 16, whereas VF was noninducible in 5. VF mapping demonstrated reentrant and focal activities (87% versus 13%, respectively) in all. The activities were dominant in one ventricle in 9 patients, whereas they had biventricular distribution in others. During sinus rhythm areas of abnormal electrograms were identified in 15/24 patients (62.5%) revealing localized structural alterations: in the right ventricle in 11, the left ventricle in 1, and both in 3. They covered a limited surface (13±6 cm) representing 5±3% of the total surface and were recorded predominantly on the epicardium. Seventy-six percent of these areas were colocated with VF drivers (<0.001). In the 9 patients without structural alteration, we observed a high incidence of Purkinje triggers (7/9 versus 4/15, =0.033). Catheter ablation resulted in arrhythmia-free outcome in 15/18 patients at 17±11 months follow-up. Conclusions - This study shows that localized structural alterations underlie a significant subset of previously unexplained sudden cardiac death. In the other subset, Purkinje electrical pathology seems as a dominant mechanism.
Liste complète des métadonnées

https://hal.umontpellier.fr/hal-01839275
Contributeur : Dominique Mornet <>
Soumis le : mercredi 29 avril 2020 - 10:42:14
Dernière modification le : vendredi 15 mai 2020 - 12:22:09

Fichier

2018 Haïssaguerre et al. Loca...
Fichiers produits par l'(les) auteur(s)

Identifiants

Citation

Michel Haïssaguerre, Mélèze Hocini, Ghassen Cheniti, Josselin Duchateau, Fréderic Sacher, et al.. Localized Structural Alterations Underlying a Subset of Unexplained Sudden Cardiac Death. Circulation. Arrhythmia and electrophysiology, Lippincott Williams & Wilkins, 2018, 11 (7), pp.e006120. ⟨10.1161/CIRCEP.117.006120⟩. ⟨hal-01839275⟩

Partager

Métriques

Consultations de la notice

542

Téléchargements de fichiers

48