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Article Dans Une Revue Neurobiology of Aging Année : 2017

The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder

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Jacques Montplaisir
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Ambra Stefani
Valérie Cochen de Cock
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Thomas Barber
Alex Desautels
Nicolas Dupre

Résumé

The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88-1.40, p = 0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.

Dates et versions

hal-01804800 , version 1 (01-06-2018)

Identifiants

Citer

Gan-Or Ziv, Jacques Montplaisir, Jay Hu, Judes Poirier, Simon Warby, et al.. The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder. Neurobiology of Aging, 2017, 49, pp.218.e13 - 218.e15. ⟨10.1016/j.neurobiolaging.2016.10.002⟩. ⟨hal-01804800⟩
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