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Article Dans Une Revue Experimental Gerontology Année : 2016

Protective effect of myostatin gene deletion on aging-related muscle metabolic decline

Béatrice Chabi
J. Carillon
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Gilles Fouret
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Béatrice Bonafos
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Barbara Vernus
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Charles Coudray
Anne Bonnieu
D. Lacan
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Résumé

While myostatin gene deletion is a promising therapy to fight muscle loss during aging, this approach induces also skeletal muscle metabolic changes such as mitochondrial deficits, redox alteration and increased fatigability. In the present study, we evaluated the effects of aging on these features in aged wild-type (WT) and mstn knockout (KO) mice. Moreover, to determine whether an enriched-antioxidant diet may be useful to prevent agerelated disorders, we orally administered to the two genotypes a melon concentrate rich in superoxide dismutase for 12 weeks. We reported that, mitochondrial functional abnormalities persisted (decreased state 3 and 4 of respiration; p<0.05) in skeletal muscle from aged KO mice, however differences with WT mice were attenuated at old age in line with reduced difference on running endurance between the two genotypes. Interestingly, we showed an increase in glutathione levels, associated with lower lipid peroxidation levels in KO muscle. Enriched antioxidant diet reduced the aging-related negative effects on maximal aerobic velocity and running limit time (p<0.05) in both groups, with systemic adaptations on body weight. The redox status and the hypertrophic phenotype appeared to be beneficial to KO mice, mitigating the effect of aging on the skeletal muscle metabolic remodeling.
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Dates et versions

hal-01804186 , version 1 (02-12-2019)

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Citer

Béatrice Chabi, M. Pauly, J. Carillon, Gilles Carnac, François Bertrand Favier, et al.. Protective effect of myostatin gene deletion on aging-related muscle metabolic decline. Experimental Gerontology, 2016, 78, pp.23 - 31. ⟨10.1016/j.exger.2016.01.016⟩. ⟨hal-01804186⟩
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