Evaluation of the New Siemens Tacrolimus Assay on the Dimension EXL Integrated Chemistry System Analyzer

Abstract : Many patients are maintained at the lower end of the tacrolimus (TAC) reference range (3-7 ng/mL), requiring the use of analytical methods displaying a very low limit of quantification for their follow-up. Therefore, the new Dimension TAC, based on affinity chrome-mediated immunoassay technology, was evaluated on the Dimension EXL Integrated Chemistry System (Siemens Healthcare Diagnostics Inc). The aims of this study were (1) to evaluate the analytical performances with special emphasis on sensibility at low levels of TAC, (2) to compare the results with an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC/MS/MS) method.
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https://hal.umontpellier.fr/hal-01803028
Contributeur : Dominique Mornet <>
Soumis le : mercredi 30 mai 2018 - 09:43:51
Dernière modification le : mercredi 29 mai 2019 - 11:46:06

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Anne-Sophie Bargnoux, Thibault Sutra, Stéphanie Badiou, Nils Kuster, Anne-Marie Dupuy, et al.. Evaluation of the New Siemens Tacrolimus Assay on the Dimension EXL Integrated Chemistry System Analyzer. Therapeutic Drug Monitoring, Lippincott, Williams & Wilkins, 2016, 38 (6), pp.808 - 812. ⟨10.1097/FTD.0000000000000331⟩. ⟨hal-01803028⟩

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