Association between breast milk fatty acids and HIV-1 transmission through breastfeeding

Abstract : A residual mother-to-child transmission of HIV through breastfeeding persists despite prophylaxis. We identified breast milk fatty acids (FA) associated with postnatal HIV transmission through breastfeeding in a case-control study. Cases (n=23) were HIV-infected women with an infant who acquired HIV after 6 weeks of age. Controls (n=23) were matched on infant׳s age at sample collection. Adjusting for maternal antenatal plasma CD4 T cell count, cis-vaccenic acid (18:1n-7) and eicosatrienoic acid (20:3n-3) were associated with HIV transmission in opposite dose-response manner: OR (tertile 3 versus tertile 1): 10.8 and 0.16, p for trend=0.02 and 0.03, respectively. These fatty acids correlated with HIV RNA load, T helper-1 related cytokines, IL15, IP10, and β2 microglobulin, positively for cis-vaccenic acid, negatively for eicosatrienoic acid. These results suggested a change in FA synthesis by mammary gland cells leading to increased cis-vaccenic acid in milk of mothers who transmitted HIV to their infant during breastfeeding.
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Dernière modification le : lundi 2 décembre 2019 - 14:35:22

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Stéphanie Badiou, E. Tuaillon, J. Viljoen, J.B. Escudié, Jean-Paul. Cristol, et al.. Association between breast milk fatty acids and HIV-1 transmission through breastfeeding. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2016, 105, pp.35 - 42. ⟨10.1016/j.plefa.2015.11.004⟩. ⟨hal-01803024⟩

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