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CASTLE tumor of the parotid: First documented case, literature review, and genetic analysis of the cancer

Abstract : BACKGROUND: Carcinoma showing thymus-like elements (CASTLE) is a rare tumor that normally affects the thyroid gland and was thought to arise from either the remnants of the branchial pouch or the ectopic cervical thymic tissue. These tumors show strong immunopositivity for CD5, P63, and CD117. Most CASTLE of the thyroid gland is treated with surgery with or without adjuvant radiotherapy or chemotherapy. METHOD: A 55-year-old woman presented with a slow-growing right parotid mass. A right total parotidectomy and ipsilateral selective neck dissection were performed and the diagnosis of CASTLE was made after confirmation with an immunohistochemistry test. She received radiotherapy postoperatively. RESULTS: Genetic sequencing showed alterations in the PPARG, BRCA2, and NOTCH1 genes. She remained disease free for >1 year after treatment. CONCLUSION: We believe that this is the first reported case of CASTLE in the parotid gland. Clinicians should be aware of this rare entity and consider this differential diagnosis after ruling out other common parotid lesions.
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https://hal.umontpellier.fr/hal-01794350
Contributeur : Mélanie Karli <>
Soumis le : jeudi 17 mai 2018 - 14:33:44
Dernière modification le : vendredi 12 juin 2020 - 16:58:20

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Eugene Hung Chih Wong, Nora Tetter, Alexandar Tzankov, Laurent Muller. CASTLE tumor of the parotid: First documented case, literature review, and genetic analysis of the cancer. Archives of Otorhinolaryngology - Head & Neck Surgery, JAMA Network- American Medical Association, 2018, 40 (1), pp.E1 - E4. ⟨10.1002/hed.24985⟩. ⟨hal-01794350⟩

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