Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs? - Université de Montpellier
Article Dans Une Revue (Article De Synthèse) Biochimie Année : 2016

Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs?

Jetty Chung-Yung Lee

Résumé

Non-enzymatic oxygenated metabolites derived from polyunsaturated fatty acids (PUFA) are formed in vivo through free radical reaction under oxidative stress conditions. It has been over twenty-five years since the discovery of cyclic oxygenated metabolites derived from arachidonic acid (20:4 n-6), the isoprostanes, and since then they have become biomarkers of choice for assessing in vivo OS in humans and animals. Chemical synthesis of n-3 PUFA isoprostanoids such as F3-Isoprostanes from eicosapentaenoic acid (20:5 n-3), and F4-Neuroprostanes from docosahexaenoic acid (22:6 n-6) unravelled novel and unexpected biological properties of such omega-3 non-enzymatic cyclic metabolites as highlighted in this review.
Fichier principal
Vignette du fichier
2016 Roy et al., non enzymatic cyclic.pdf (25.59 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-01786233 , version 1 (09-12-2019)

Identifiants

Citer

Jérôme Roy, Jean-Yves Le Guennec, Jean-Marie Galano, Jérôme Thireau, Valérie Bultel-Poncé, et al.. Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs?. Biochimie, 2016, 120, pp.56 - 61. ⟨10.1016/j.biochi.2015.06.010⟩. ⟨hal-01786233⟩
209 Consultations
193 Téléchargements

Altmetric

Partager

More