Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs?

Abstract : Non-enzymatic oxygenated metabolites derived from polyunsaturated fatty acids (PUFA) are formed in vivo through free radical reaction under oxidative stress conditions. It has been over twenty-five years since the discovery of cyclic oxygenated metabolites derived from arachidonic acid (20:4 n-6), the isoprostanes, and since then they have become biomarkers of choice for assessing in vivo OS in humans and animals. Chemical synthesis of n-3 PUFA isoprostanoids such as F3-Isoprostanes from eicosapentaenoic acid (20:5 n-3), and F4-Neuroprostanes from docosahexaenoic acid (22:6 n-6) unravelled novel and unexpected biological properties of such omega-3 non-enzymatic cyclic metabolites as highlighted in this review.
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Biochimie, Elsevier, 2016, 120, pp.56 - 61. 〈10.1016/j.biochi.2015.06.010〉
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Soumis le : samedi 5 mai 2018 - 10:38:12
Dernière modification le : dimanche 24 juin 2018 - 13:24:02

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Jérôme Roy, Jean-Yves Le Guennec, Marie Galano, Jérôme Thireau, Valérie Bultel-Poncé, et al.. Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs?. Biochimie, Elsevier, 2016, 120, pp.56 - 61. 〈10.1016/j.biochi.2015.06.010〉. 〈hal-01786233〉

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