Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs?

Abstract : Non-enzymatic oxygenated metabolites derived from polyunsaturated fatty acids (PUFA) are formed in vivo through free radical reaction under oxidative stress conditions. It has been over twenty-five years since the discovery of cyclic oxygenated metabolites derived from arachidonic acid (20:4 n-6), the isoprostanes, and since then they have become biomarkers of choice for assessing in vivo OS in humans and animals. Chemical synthesis of n-3 PUFA isoprostanoids such as F3-Isoprostanes from eicosapentaenoic acid (20:5 n-3), and F4-Neuroprostanes from docosahexaenoic acid (22:6 n-6) unravelled novel and unexpected biological properties of such omega-3 non-enzymatic cyclic metabolites as highlighted in this review.
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https://hal.umontpellier.fr/hal-01786233
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Dernière modification le : mercredi 18 décembre 2019 - 15:44:13

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2016 Roy et al., non enzymatic...
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Jérôme Roy, Jean-Yves Le Guennec, Marie Galano, Jérôme Thireau, Valérie Bultel-Poncé, et al.. Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs?. Biochimie, Elsevier, 2016, 120, pp.56 - 61. ⟨10.1016/j.biochi.2015.06.010⟩. ⟨hal-01786233⟩

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