Dietary silicon-enriched spirulina improves early atherosclerosis markers in hamsters on a high-fat diet

Abstract : Objective: The aim of this study was to investigate the effects of dietary silicon-enriched spirulina (SES) on atherosclerosis. Methods: Hamsters (six per group) on a high-fat (HF) diet received SES or non-enriched spirulina (both at 57 mg/kg body weight) daily. This corresponded to 0.57 mg silicon/kg body weight daily. Results: The HF diet induced dyslipidemia, insulin resistance, oxidative stress, and vascular dysfunction. Compared with the HF group, SES attenuated increases of lipemia and prevented insulin resistance (IR) (P ¼ 0.001). SES protected against oxidative stress through a reduction of heart (P ¼ 0.006) and liver (P < 0.0001) nicotinamide adenine dinucleotide phosphate-oxidase activity and by sparing the activity of superoxide dismutase (P ¼ 0.0017) and glutathione perox-idase (P ¼ 0.01861). SES decreased inflammation, lowering tumor necrosis factor-a (P ¼ 0.0006) and interleukin-6 levels (P ¼ 0.0112), decreasing polymorphonuclear cells and preventing nuclear factor-kB activity (P ¼ 0.0259). SES corrected plasma level of monocyte chemoattractant protein-1 (P ¼ 0.0380), which was increased by the HF diet. Finally, SES supplementation prevented vascular and endothelial functions assessed respectively by the contractile response to the agonist phen-ylephrine and the relaxation induced by acetylcholine. Conclusion: SES protects against metabolic imbalance, inflammation, oxidative stress, and vascular dysfunction induced by an HF diet, and could prevent the atherogenic processes. Synergistic effects between spirulina and silicon were observed.
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2015 Vidé et al., Nutrition_2...
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Joris Vidé, Anne Virsolvy, Cindy Romain, Jeanne Ramos, Nicolas Jouy, et al.. Dietary silicon-enriched spirulina improves early atherosclerosis markers in hamsters on a high-fat diet. Nutrition, Elsevier, 2015, 31 (9), pp.1148 - 1154. ⟨10.1016/j.nut.2015.03.014⟩. ⟨hal-01762603⟩



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