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Article Dans Une Revue European Respiratory Journal Année : 2017

Two-year follow-up after endobronchial coil treatment in emphysema: results from the REVOLENS study

Vincent Jounieaux
Mathieu Salaün
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Coralie Barbe
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Résumé

Severe emphysema is a difficult to treat condition with limited efficacy of currently available treatments. Endobronchial coil treatment (ECT) is a minimally invasive endobronchial treatment which consists of placing shape-memory nitinol coils in emphysematous lobes to enhance lung recoil and reduce lung hyperinflation at rest and during exercise [1, 2]. Randomised studies demonstrated an improvement in exercise capacity, lung function and quality of life, and showed an acceptable safety profile at 1 year [3–6]. However, to our best knowledge, longer term safety and effectiveness results beyond 1 year have not been reported thus far. REVOLENS (Réduction volumique endobronchique par spirales) (NCT01822795) is a 1:1 randomised controlled study of 100 patients (50 patients treated with coils and optimal medical management and 50 patients treated with optimal medical management only) in 10 centres across France. Patients treated with optimal medical management only were offered coil treatment after 1 year. The study protocol [7] and 1-year results [5] of the REVOLENS study have been previously described, demonstrating a decrease in lung hyperinflation and improvement in quality of life. In the present study, we analysed efficacy and safety data at 2 years in the 50 patients randomised to the ECT group.
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Dates et versions

hal-01745528 , version 1 (08-04-2020)

Identifiants

Citer

Gaëtan Deslee, Sylvie Leroy, Jeanne Marie Perotin, Herve Mal, Hervé Dutau, et al.. Two-year follow-up after endobronchial coil treatment in emphysema: results from the REVOLENS study. European Respiratory Journal, 2017, 50 (6), pp.1701740. ⟨10.1183/13993003.01740-2017⟩. ⟨hal-01745528⟩
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