Fiber atrophy, oxidative stress, and oxidative fiber reduction are the attributes of different phenotypes in chronic obstructive pulmonary disease patients

Abstract : Fiber atrophy, oxidative stress, and oxidative fiber reduction are the attributes of different phenotypes in chronic obstructive pulmonary disease patients..—Peripheral muscle dysfunction, associated with reductions in fiber cross-sectional area (CSA) and in type I fibers, is a key outcome in chronic obstructive pulmonary disease (COPD). However, COPD peripheral muscle function and structure show great heterogeneity, overlapping those in sedentary healthy subjects (SHS). While discrepancies in the link between muscle structure and phenotype remain unexplained, we tested whether the fiber CSA and the type I fiber reductions were the attributes of different phenotypes of the disease, using unsupervised clustering method and post hoc validation. Principal component analysis performed on functional and histomorphological parameters in 64 COPD patients {forced expiratory volume in 1 s (FEV1) 42.0 [30.0 –58.5]% predicted} and 27 SHS (FEV 1 105.0 [95.0 –114.0]% predicted) revealed two COPD clusters with distinct peripheral muscle dysfunctions. These two clusters had different type I fiber proportion (26.0 14.0% vs. 39.8 12.6%; P 0.05), and fiber CSA (3,731 1,233 vs. 5,657 1,098 m 2 ; P 0.05). The " atrophic " cluster showed an increase in muscle protein carbonylation (131.5 [83.6 –200.3] vs. 83.0 [68.3–105.1]; P 0.05). Then, COPD patients underwent pulmonary rehabilitation. If the higher risk of exacerba-tions in the " atrophic " cluster did not reach statistical significance after adjustment for FEV1 (hazard ratio: 2.43; P 0.11, n 54), the improvement of VO 2sl after training was greater than in the nonatro-phic cluster (24 16% vs. 6 13%; P 0.01). Last, their age was similar (60.4 8.8 vs. 60.8 9.0 yr; P 0.87), suggesting a different time course of the disease. We identified and validated two phenotypes of COPD patients showing different muscle histomor-phology and level of oxidative stress. Thus our study demonstrates that the muscle heterogeneity is the translation of different phenotypes of the disease.
Type de document :
Article dans une revue
Journal of Applied Physiology, American Physiological Society, 2013, 115 (12), pp.1796 - 1805. 〈10.1152/japplphysiol.00778.2013〉
Liste complète des métadonnées

Littérature citée [53 références]  Voir  Masquer  Télécharger

https://hal.umontpellier.fr/hal-01623970
Contributeur : Fares Gouzi <>
Soumis le : mercredi 25 octobre 2017 - 22:10:10
Dernière modification le : mardi 17 juillet 2018 - 15:56:02
Document(s) archivé(s) le : vendredi 26 janvier 2018 - 16:07:14

Fichier

Fiber atrophy oxidative stress...
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Citation

Fares Gouzi, Aldjia Abdellaoui, Nicolas Molinari, Edith Pinot, Bronia Ayoub, et al.. Fiber atrophy, oxidative stress, and oxidative fiber reduction are the attributes of different phenotypes in chronic obstructive pulmonary disease patients. Journal of Applied Physiology, American Physiological Society, 2013, 115 (12), pp.1796 - 1805. 〈10.1152/japplphysiol.00778.2013〉. 〈hal-01623970〉

Partager

Métriques

Consultations de la notice

305

Téléchargements de fichiers

33