Context. Stellar activity limits the radial velocity (RV) search and characterisation of exoplanets, as it introduces spurious noise (called jitter) in the data sets and prevents the correct retrieval of a planetary signal. This is key for M dwarfs, considering that they manifest high activity levels and are primary targets for present and future searches of habitable Earth-like planets. To perform precise RV measurements, multi-line numerical techniques like cross-correlation and least-squares deconvolution (LSD) are typically employed.Aims. Effective filtering of activity is crucial to achieving the sensitivity required for small planet detections. Here we analyse the impact of selecting different line lists for LSD on the dispersion in our RV data sets, to identify the line list that most effectively reduces the jitter.Methods. We employ optical spectropolarimetric observations of the active M dwarf EV Lac collected with ESPaDOnS and NARVAL, and study two line down-selection approaches: a parametric method based on line properties (depth, wavelength, magnetic sensitivity) and a randomised algorithm that samples the line combination space. We test the latter further to find the line list that singles out the activity signal from other sources of noise, and on AD Leo and DS Leo to examine its consistency at mitigating jitter for different activity levels. The analysis is complemented with planetary injection tests.Results. The parametric selection yields a RV RMS reduction of less than 10%, while the randomised selection yields a systematic improvement (>50%) regardless of the activity level of the star examined. Furthermore, if activity is the dominant source of noise, this approach allows the construction of lists containing mainly activity-sensitive lines, which could be used to enhance the rotational modulation of the resulting data sets and determine the stellar rotation period more robustly. Finally, the output line lists allow the recovery of a synthetic planet (0.3–0.6 MJup on a 10 d orbit) in the presence of both moderate (20 m s−1 semi-amplitude) and high (200 m s−1) activity levels, without substantially affecting the planet signal (between 60 and 120 m s−1).