The Hydrazine Moiety in the Synthesis of Modified Nucleosides and Nucleotides - Université de Montpellier
Article Dans Une Revue ChemMedChem Année : 2024

The Hydrazine Moiety in the Synthesis of Modified Nucleosides and Nucleotides

Résumé

Synthetic nucleoside mimics are re-emerging as crucial contenders for antiviral and anticancer medications. While, Ribavirin stands out for its unique antiviral properties, predominantly associated with its distinctive triazole heterocycle as a nucleobase, the exploration of alternative nitrogen-based aromatic heterocycles hold great promises for the discovery of novel bioactive nucleoside mimics. Although nucleoside derivatives synthesised from hydrazine-ribose units have been in development for many decades, they have been little evaluated biologically and even less for their antiviral properties. With the aim of taking a closer look at these under-explored derivatives and investigating their synthetic pathways, this review provides an overview of the molecular design, the chemical synthesis, and the biological activity, when available, of these nucleoside analogues. Overall, the entire body of work already done motivates further exploration of theses analogues and encourages us of formulating structurally novel nucleoside drug candidates featuring innovative mode of action.

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jeudi 30 octobre 2025
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hal-04759698 , version 1 (30-10-2024)

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Anaïs Guillou, Suzanne Peyrottes, Jean‐jacques Vasseur, Christophe Mathé, Michael Smietana. The Hydrazine Moiety in the Synthesis of Modified Nucleosides and Nucleotides. ChemMedChem, 2024, 19, ⟨10.1002/cmdc.202400234⟩. ⟨hal-04759698⟩
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