Detrital zircons from two samples of metasandstones from the Lykhmanivka Syncline, Middle Dnieper Domain of the Ukrainian Shield (Skelevate Formation of the Kryvyi Rih Group), have been dated by the LA-ICP-MS U-Pb method. Metasandstones from the northern part of the syncline yield zircons belonging to four age groups: 3201 ± 12 Ma, 3089 ± 11 Ma, 2939 ± 8 Ma, and 2059 ± 4 Ma. All three Archean groups originated from similar rock types that crystallized at different times from the same mafic source (lower crust) with a 176Lu/177Hf ratio of about 0.020. In contrast, zircon from metasediments from the southern end of the Lykhmanivka Syncline fall within two age groups: 3174 ± 13 Ma, and 2038 ± 9 Ma. In terms of Hf isotope compositions, the detrital zircons from the two oldest age groups in both samples are very similar. The source area was dominated by rocks of the Auly Group (3.27–3.18 Ga) and the Sura Complex (3.17–2.94 Ga). The proportion of zircons dated at 2.07–2.03 Ga, which reflects the timing of metamorphism, is 5%. The metamorphic nature of the Paleoproterozoic zircon allows us to define the maximum depositional age of the metasandstones of the Lykhmanivka Syncline at ca. 2.9 Ga, which is in good agreement with the earlier results from the metaterrigenous rocks of the Kryvyi Rih–Kremenchuk Basin. Our data also indicate the local nature of sedimentation and the absence of significant transport and mixing of detrital material within the basin.