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Periodic Mesoporous Ionosilica Nanoparticles for BODIPY Delivery and Photochemical Internalization of siRNA Braham Mezghrani 2244112-0 Lamiaa Ali 6b7d273aa4abb1068db3f7c31b55b4e8 umontpellier.fr 797607 1680132-797607 https://orcid.org/0000-0003-1176-5335 Sara Jakimoska 2781004-0 Frédérique Cunin 42da46c9d12200b5ba6411a2e586c941 enscm.fr frederique-cunin 743160 211036-743160 https://orcid.org/0000-0003-4624-8418 https://www.idref.fr/165812168 Peter Hesemann 01f10923d134845a615abb8f0e81f14c umontpellier.fr peter-hesemann 10228 4826-10228 https://orcid.org/0000-0001-5266-9791 https://www.idref.fr/164127313 Jean-Olivier Durand a32b00651a0d4d18efb998662c4025fb umontpellier.fr jodurand 760781 239698-760781 https://orcid.org/0000-0003-4606-2576 https://www.idref.fr/120153912 Nadir Bettache b68449b37cf89bdb7d90df04019bdd50 umontpellier.fr nadir-bettache 742291 52254-742291 https://orcid.org/0000-0001-5426-7024 ICG AIGLe 651d2bf5a975fe105c63cec2cdbb5cac cnrs.fr 2023-05-30 16:25:16 2026-01-09 21:10:02 2023-05-31 07:41:57 2023-03 2023-05-30 contributor ICG AIGLe 651d2bf5a975fe105c63cec2cdbb5cac cnrs.fr CCSD hal-04062152 https://hal.umontpellier.fr/hal-04062152 mezghrani:hal-04062152 <i>ChemPlusChem</i>, 2023, 88 (3), pp.e202300021. <a target="_blank" href="https://dx.doi.org/10.1002/cplu.202300021">⟨10.1002/cplu.202300021⟩</a> ChemPlusChem, 2023, 88 (3), pp.e202300021. ⟨10.1002/cplu.202300021⟩ CC BY-NC-ND 4.0 - Attribution - Non-commercial use - No Derivative Works CNRS - Centre national de la recherche scientifique Ecole Nationale Supérieure de Chimie de Montpellier Institut Charles Gerhardt - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut des Biomolécules Max Mousseron Institut de Chimie du CNRS Chimie Université de Montpellier ANR Université de Montpellier (2015-2021) Université de Montpellier - EPE International No Yes Periodic Mesoporous Ionosilica Nanoparticles for BODIPY Delivery and Photochemical Internalization of siRNA Braham Mezghrani 2244112-0 Lamiaa Ali 6b7d273aa4abb1068db3f7c31b55b4e8 umontpellier.fr 797607 1680132-797607 https://orcid.org/0000-0003-1176-5335 Sara Jakimoska 2781004-0 Frédérique Cunin 42da46c9d12200b5ba6411a2e586c941 enscm.fr frederique-cunin 743160 211036-743160 https://orcid.org/0000-0003-4624-8418 https://www.idref.fr/165812168 Peter Hesemann 01f10923d134845a615abb8f0e81f14c umontpellier.fr peter-hesemann 10228 4826-10228 https://orcid.org/0000-0001-5266-9791 https://www.idref.fr/164127313 Jean-Olivier Durand a32b00651a0d4d18efb998662c4025fb umontpellier.fr jodurand 760781 239698-760781 https://orcid.org/0000-0003-4606-2576 https://www.idref.fr/120153912 Nadir Bettache b68449b37cf89bdb7d90df04019bdd50 umontpellier.fr nadir-bettache 742291 52254-742291 https://orcid.org/0000-0001-5426-7024 123944 2192-6506 ChemPlusChem Wiley 88 3 e202300021 2023-03 10.1002/cplu.202300021 36779542 English BODIPY Drug delivery Periodic mesoporous ionosilica nanoparticles Photochemical internalization siRNA RNA, Small Interfering Photochemotherapy Luciferases Nanoparticles Chemical Sciences Journal articles Journal articles Journal articles

Periodic Mesoporous Ionosilica Nanoparticles (PMINPs) made via co-condensation reactions starting from an ionosilica precursor and a porphyrin derivative were used for simultaneous BODIPY/siRNA delivery in cancer cells. We observed high BODIPY loading capacities and efficiencies of the PMINPs that are triggered by anion exchange. siRNA adsorption took place on the surface of the nanoparticles, whereas BODIPY was encapsulated within the core of the nanoparticles. BODIPY release was found to be pH-dependent. Our results indicate 94 % BODIPY release after 16 h at pH 4, whereas only 2% were released at pH 7.4. Furthermore, complexation with siRNA against luciferase gene was observed at the surface of PMINPs and gene silencing through its delivery via photochemical internalization (PCI) mechanism was efficient in MDA-MB-231 breast cancer cells expressing stable luciferase.

0000000123688723 200711918D https://ror.org/028wq3277 Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier ICGM 2022-01-01

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