Abstract The assessment of zooplankton spatial structure is critical to quantifying plankton production and biochemical cycling. Here, we show the effect of monsoon-driven hydrographic changes on the spatial patterns of zooplankton at regional scales. Based on a field survey conducted during the monsoon transition, we assess the community structure and ash-free dry weight above 100 m depth in the Kuroshio edge area, southeastern East China Sea. The zooplankton community was dominated by copepods, with calanoids as the most abundant taxon followed by poecilostomatoids. Copepod assemblages comprised 81 species belonging to 41 families, and 23 genera, with Undinula vulgaris as the most abundant species. The richness of zooplankton taxa showed a mounting trend from the coast to offshore, which was opposite to the spatial variation of total zooplankton biomass. Our results suggest a leading influence of the Kuroshio Current during the southwest-northeast monsoon transition period in the southeastern East China Sea.