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Article Dans Une Revue European Respiratory Journal Année : 2022

Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children

Evelien van Meel (1, 2) , Sara Mensink-Bout (1, 2) , Herman den Dekker (1, 2, 3) , Tarunveer Ahluwalia (4) , Isabella Annesi‐maesano (5, 6) , Syed Hasan Arshad (7, 8) , Nour Baiz (6) , Henrique Barros (9, 10) , Andrea von Berg (11) , Hans Bisgaard (4) , Klaus Bønnelykke (4) , Christian J. Carlsson (4) , Maribel Casas (12, 13, 14) , Leda Chatzi (15) , Cécile Chevrier (16) , Geertje Dalmeijer (17) , Carol Dezateux (18) , Karel Duchen (19) , Merete Eggesbø (20) , Cornelis van Der Ent (21) , Maria Pia Fantini (22) , Claudia Flexeder (23) , Urs Frey (24) , Fransesco Forastiere (25) , Ulrike Gehring (26) , Davide Gori (22) , Raquel Granell (27) , Lucy J. Griffiths (28) , Hazel Inskip (8, 29) , Joanna Jerzynska (30) , Anne M. Karvonen (31) , Thomas Keil (32, 33, 34) , Cecily C Kelleher (35) , Manolis Kogevinas (12, 13, 36, 37) , Gudrun Koppen (38) , Claudia E. Kuehni (39, 40) , Nathalie Lambrechts (38) , Susanne Lau (32) , Irina Lehmann (41) , Johnny Ludvigsson (19) , Maria Christine Magnus (42, 20) , Erik Melén (43) , John Mehegan (35) , Monique Mommers (44) , Anne-Marie Nybo Andersen (45) , Wenche Nystad (20) , Eva S. L. Pedersen (39) , Juha Pekkanen (31, 46) , Ville T. Peltola (47) , Katharine C. Pike (48) , Angela Pinot de Moira (49) , Costanza Pizzi (50) , Kinga Polanska (30) , Maja Popovic (50) , Daniela Porta (25) , Graham Roberts (51, 29, 8) , Ana Cristina Santos (10) , Erica S. Schultz (52) , Marie Standl (23, 53) , Jordi Sunyer (12, 13, 14, 37) , Thijs Carel (44) , Laura Toivonen (47) , Eleonora P. Uphoff (54) , Jakob Usemann (24) , Marina Vafeidi (55) , John W. Wright (54) , Johan C. de Jongste (2) , Vincent W. V. Jaddoe (1, 2) , Liesbeth Duijts (2)
1 The Generation R Study Group
2 Erasmus MC - Erasmus University Medical Center [Rotterdam]
3 Department of Epidemiology, Erasmus University Medical Center, Rotterdam
4 Herlev and Gentofte Hospital
5 IDESP - Institut Desbrest de santé publique
6 EPAR - Epidemiology of Allergic and Respiratory Diseases Department [iPlesp]
7 St Mary's Hospital [London]
8 University Hospital Southampton NHS Foundation Trust
9 Departamento de Ciências da Saúde Pública e Forenses e Educação Médica [Porto, Portugal]
10 ISPUP-EPIUnit, University of Porto Medical School and Institute of Public Health
11 Marien-Hospital Wesel gGmbH
12 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
13 UPF - Universitat Pompeu Fabra [Barcelona]
14 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
15 USC - University of Southern California
16 Irset - Institut de recherche en santé, environnement et travail
17 Julius Center for Health Sciences and Primary Care
18 Barts & The London School of Medicine and Dentistry
19 Linköping university hospital
20 NIPH - Norwegian Institute of Public Health [Oslo]
21 UMCU - University Medical Center [Utrecht]
22 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
23 HMGU - Helmholtz Zentrum München = German Research Center for Environmental Health
24 UKBB - University Children’s Hospital Basel = Hôpital pédiatrique universitaire des deux Bâle [Bâle, Suisse]
25 Lazio Regional Health Service [Rome]
26 IRAS - Institute for Risk Assessment Sciences [Utrecht]
27 MRC IEU - MRC Integrative Epidemiology Unit [Bristol, Royaume-Uni]
28 Swansea University Medical School
29 University of Southampton
30 NIOM - Nofer Institute of Occupational Medicine
31 FIHW - Finnish Institute for Health and Welfare
32 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
33 JMU - Julius-Maximilians-Universität Würzburg = University of Würzburg
34 Bavarian Health and Food Safety Authority
35 School of Public Health, Physiotherapy and Sports Science [Dublin, Irlande]
36 National School of Public Health [Athens]
37 IMIM-Hospital del Mar
38 VITO - Flemish Institute for Technological Research
39 ISPM - Institute of Social and Preventive Medicine [Bern]
40 Inselspital - Bern University Hospital [Berne]
41 UFZ - Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research
42 University of Bristol [Bristol]
43 Sach's Children's Hospital [Stockholm]
44 MUMC - Maastricht University Medical Centre
45 UCPH - University of Copenhagen = Københavns Universitet
46 TKK - TKK Helsinki University of Technology
47 University of Turku
48 Bristol Royal Hospital for Children
49 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
50 DMS - Department of Medical Sciences [Turin, Italy]
51 The David Hide Asthma and Allergy Research Centre
52 Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm
53 German Research Center for Environmental Health - Helmholtz Center München (GmbH)
54 BIHR - Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
55 UOC - University of Crete [Heraklion]
Cornelis van Der Ent
  • Fonction : Auteur
  • PersonId : 881511
Wenche Nystad
  • Fonction : Auteur
  • PersonId : 886673
Ville T. Peltola
Laura Toivonen
  • Fonction : Auteur
  • PersonId : 1088401

Résumé

Background Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Objective To examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school-age. Methods We used individual-participant data of 150 090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6 months to 5 years with forced expiratory volume in 1 s (FEV 1 ), forced vital capacity (FVC), FEV 1 /FVC, forced expiratory flow at 75% of FVC (FEF 75 ), and asthma at a median age of 7 (range 4 to 15) years. Results Children with early-life lower, not upper, respiratory tract infections had a lower school-age FEV 1 , FEV 1 /FVC and FEF 75 (Z-score (95% CI): ranging from −0.09 (−0.14, −0.04) to −0.30 (−0.36, −0.24)). Children with early-life lower respiratory tract infections had a higher increased risk of school-age asthma than those with upper respiratory tract infections (OR (95%CI): ranging from 2.10 (1.98, 2.22) to 6.30 (5.64, 7.04)), and from 1.25 (1.18, 1.32) to 1.55 (1.47, 1.65)), respectively). Adjustment for preceding respiratory tract infections slightly decreased the strength of the effects. Observed associations were similar for those with and without early-life wheezing as proxy for early-life asthma. Conclusion Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower upper respiratory tract infections.
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hal-03677179 , version 1 (15-02-2024)

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Evelien van Meel, Sara Mensink-Bout, Herman den Dekker, Tarunveer Ahluwalia, Isabella Annesi‐maesano, et al.. Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children. European Respiratory Journal, 2022, 60, pp.2102395. ⟨10.1183/13993003.02395-2021⟩. ⟨hal-03677179⟩
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