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 Imidazopyridine-fused [1,3]-diazepinones part 2: Structure-activity relationships and antiproliferative activity against melanoma cells Virginie Bellet 476fa7163f8bb7644a71eb53309914e9 umontpellier.fr virginie-bellet 1256892 812238-1256892 https://orcid.org/0000-0001-7337-5303 https://www.idref.fr/076951367 https://viaf.org/viaf/207038025 http://isni.org/isni/0000000140606478 Laure Lichon e90033f7a29dcfbeb68a283a66133239 univ-montp1.fr 1275332 954546-1275332 Dominique Arama 2134713-0 Audrey Gallud 702054-0 Vincent Lisowski 6e0b660f8d21fd940ecd1c913404f1bc umontpellier.fr 1096014 188855-1096014 https://orcid.org/0000-0002-4474-4242 https://www.idref.fr/081276222 Ludovic Maillard 7251175e71fc53f942f017644573a86a umontpellier.fr ludovic-t-maillard 767790 688231-767790 https://orcid.org/0000-0002-9437-9765 https://www.idref.fr/103785973 Marcel Garcia 190251-0 Jean Martinez 133961-0 Nicolas Masurier 4875547391631510649479d14fc54791 umontpellier.fr nmasurier 1086355 547511-1086355 https://orcid.org/0000-0001-9169-8149 https://www.idref.fr/07356902X Anthony Herrada fcb22fb3703cf470da2926a2fd72f58a unimes.fr 2022-02-10 14:33:03 2024-06-12 17:38:20 2022-02-10 14:33:03 2017-01 contributor Anthony Herrada fcb22fb3703cf470da2926a2fd72f58a unimes.fr CCSD hal-03564436 https://hal.umontpellier.fr/hal-03564436 bellet:hal-03564436 <i>European Journal of Medicinal Chemistry</i>, 2017, 125, pp.1225-1234. <a target="_blank" href="https://dx.doi.org/10.1016/j.ejmech.2016.11.023">&#x27E8;10.1016/j.ejmech.2016.11.023&#x27E9;</a> European Journal of Medicinal Chemistry, 2017, 125, pp.1225-1234. &#x27E8;10.1016/j.ejmech.2016.11.023&#x27E9; CNRS - Centre national de la recherche scientifique Ecole Nationale Supérieure de Chimie de Montpellier Institut des Biomolécules Max Mousseron Institut de Chimie du CNRS Chimie Université de Montpellier Université de Montpellier (2015-2021) International No Yes Imidazopyridine-fused [1,3]-diazepinones part 2: Structure-activity relationships and antiproliferative activity against melanoma cells Virginie Bellet 476fa7163f8bb7644a71eb53309914e9 umontpellier.fr virginie-bellet 1256892 812238-1256892 https://orcid.org/0000-0001-7337-5303 https://www.idref.fr/076951367 https://viaf.org/viaf/207038025 http://isni.org/isni/0000000140606478 Laure Lichon e90033f7a29dcfbeb68a283a66133239 univ-montp1.fr 1275332 954546-1275332 Dominique Arama 2134713-0 Audrey Gallud 702054-0 Vincent Lisowski 6e0b660f8d21fd940ecd1c913404f1bc umontpellier.fr 1096014 188855-1096014 https://orcid.org/0000-0002-4474-4242 https://www.idref.fr/081276222 Ludovic Maillard 7251175e71fc53f942f017644573a86a umontpellier.fr ludovic-t-maillard 767790 688231-767790 https://orcid.org/0000-0002-9437-9765 https://www.idref.fr/103785973 Marcel Garcia 190251-0 Jean Martinez 133961-0 Nicolas Masurier 4875547391631510649479d14fc54791 umontpellier.fr nmasurier 1086355 547511-1086355 https://orcid.org/0000-0001-9169-8149 https://www.idref.fr/07356902X 12364 0223-5234 1768-3254 European Journal of Medicinal Chemistry Elsevier 125 1225-1234 2017-01 10.1016/j.ejmech.2016.11.023 27871038 English Polyfused heterocycles Melanoma 2-a]pyridine Imidazo[1 Diazepinones Antitumor activity Antineoplastic Agents Azepines Cell Line, Tumor Cell Proliferation Drug Screening Assays, Antitumor Humans Melanoma Pyridines Structure-Activity Relationship Chemical Sciences Journal articles Journal articles Journal articles

We recently described a pyrido-imidazodiazepinone derivative which could be a promising hit compound for the development of new drugs acting against melanoma cells. In this study, a series of 28 novel pyrido-imidazodiazepinones were synthesized and screened for their in vitro cytotoxic activities against the melanoma MDA-MB-435 cell line. Among the derivatives, seven of them showed 50% growth inhibitory activity at 1 μM concentration, and high selectivity against the melanoma cell line MDA-MB-435.

 200711912X https://ror.org/05d1e6v30 Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] IBMM 2006-01-01 2021-12-31
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