Childhood maltreatment and clinical severity of treatment‐resistant depression in a French cohort of outpatients (FACE‐DR): One‐year follow‐up
Antoine Yrondi
(1, 2, 3)
,
Bruno Aouizerate
(1, 4, 5)
,
Djamila Bennabi
(1, 6, 7)
,
Raphaëlle Richieri
(1, 8)
,
Thierry d'Amato
(1, 9, 10)
,
Frank Bellivier
(1, 11, 12)
,
Thierry Bougerol
(1)
,
Mathilde Horn
(1, 13)
,
Vincent Camus
(1, 14, 15)
,
Philippe Courtet
(1, 16, 17)
,
Olivier Doumy
(1, 4, 5)
,
Jean Genty
(1, 18)
,
Jérôme Holtzmann
(1, 19)
,
Christophe Lancon
(1, 6, 7)
,
Marion Leboyer
(1, 18, 20)
,
Pierre Llorca
(1, 21)
,
Julia Maruani
(1, 11, 12)
,
Remi Moirand
(1, 9)
,
Fanny Molière
(1, 17, 16)
,
Ludovic Samalin
(1, 21)
,
Laurent Schmitt
(1, 22)
,
Florian Stephan
(1, 23)
,
Gustavo Turecki
(24)
,
Guillame Vaiva
(1, 25)
,
Michel Walter
(1, 23)
,
Jean Petrucci
(1, 18)
,
Emmanuel Haffen
(1, 6, 7)
,
Wissam El-Hage
(1, 14, 15)
1
Fondation FondaMental [Créteil]
2 Service Psychiatrie et psychologie médicale [CHU Toulouse]
3 ToNIC - Toulouse NeuroImaging Center
4 Centre hospitalier Charles Perrens [Bordeaux]
5 NutriNeuro - Nutrition et Neurobiologie intégrée
6 Inserm CIC 1431 - Centre d'Investigation Clinique de Besançon
7 NEURO - Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481)
8 LA CONCEPTION - Hôpital de la Conception [CHU - APHM]
9 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
10 Centre Hospitalier le Vinatier [Bron]
11 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
12 OPTeN (UMR_S 1144 / U1144) - Optimisation thérapeutique en Neuropsychopharmacologie
13 Service de Psychiatrie [CHRU Lille]
14 iBraiN - Imaging, Brain & Neuropsychiatry
15 CIC - Centre d’Investigation Clinique [Tours] CIC 1415
16 PSNREC - Neuropsychiatrie : recherche épidémiologique et clinique
17 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
18 U955 Inserm - UPEC - IMRB - "Neuropsychiatrie translationnelle" [Créteil]
19 GIN - [GIN] Grenoble Institut des Neurosciences
20 Pôle de Psychiatrie [Hôpital Henri Mondor]
21 CHU Clermont-Ferrand
22 Pôle Neurosciences [CHU Toulouse]
23 CHU - BREST - Hopital de Bohars - CHRU Brest
24 Douglas Mental Health University Institute [Montréal]
25 CN2R - Centre National de Ressources et de Résilience [Lille]
2 Service Psychiatrie et psychologie médicale [CHU Toulouse]
3 ToNIC - Toulouse NeuroImaging Center
4 Centre hospitalier Charles Perrens [Bordeaux]
5 NutriNeuro - Nutrition et Neurobiologie intégrée
6 Inserm CIC 1431 - Centre d'Investigation Clinique de Besançon
7 NEURO - Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481)
8 LA CONCEPTION - Hôpital de la Conception [CHU - APHM]
9 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
10 Centre Hospitalier le Vinatier [Bron]
11 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
12 OPTeN (UMR_S 1144 / U1144) - Optimisation thérapeutique en Neuropsychopharmacologie
13 Service de Psychiatrie [CHRU Lille]
14 iBraiN - Imaging, Brain & Neuropsychiatry
15 CIC - Centre d’Investigation Clinique [Tours] CIC 1415
16 PSNREC - Neuropsychiatrie : recherche épidémiologique et clinique
17 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
18 U955 Inserm - UPEC - IMRB - "Neuropsychiatrie translationnelle" [Créteil]
19 GIN - [GIN] Grenoble Institut des Neurosciences
20 Pôle de Psychiatrie [Hôpital Henri Mondor]
21 CHU Clermont-Ferrand
22 Pôle Neurosciences [CHU Toulouse]
23 CHU - BREST - Hopital de Bohars - CHRU Brest
24 Douglas Mental Health University Institute [Montréal]
25 CN2R - Centre National de Ressources et de Résilience [Lille]
Antoine Yrondi
- Fonction : Auteur
- PersonId : 785942
- ORCID : 0000-0002-2650-6080
- IdRef : 177141042
Bruno Aouizerate
- Fonction : Auteur
- PersonId : 751079
- IdHAL : bruno-aouizerate
- ORCID : 0000-0002-7092-7747
- IdRef : 069471851
Thierry d'Amato
- Fonction : Auteur
- PersonId : 1290580
- ORCID : 0000-0001-8983-0315
Frank Bellivier
- Fonction : Auteur
- PersonId : 757742
- ORCID : 0000-0002-3660-6640
- IdRef : 070265062
Vincent Camus
- Fonction : Auteur
- PersonId : 20005
- IdHAL : vincent-b-camus
- ORCID : 0000-0002-6845-221X
- IdRef : 034516565
Philippe Courtet
- Fonction : Auteur
- PersonId : 833371
- ORCID : 0000-0002-6519-8586
- IdRef : 060385022
Christophe Lancon
- Fonction : Auteur
- PersonId : 946496
- ORCID : 0000-0002-0661-5781
- IdRef : 067155677
Marion Leboyer
- Fonction : Auteur
- PersonId : 756830
- ORCID : 0000-0001-5473-3697
- IdRef : 089352475
Laurent Schmitt
- Fonction : Auteur
- PersonId : 759208
- ORCID : 0000-0002-7203-6032
- IdRef : 071007482
Gustavo Turecki
- Fonction : Auteur
- PersonId : 769354
- ORCID : 0000-0003-4075-2736
Emmanuel Haffen
- Fonction : Auteur
- PersonId : 753044
- IdHAL : emmanuel-haffen
- ORCID : 0000-0002-4091-518X
- IdRef : 068887825
Wissam El-Hage
- Fonction : Auteur
- PersonId : 183525
- IdHAL : wissam-el-hage
- ORCID : 0000-0003-3877-0855
- IdRef : 068549679
Résumé
Childhood maltreatment is associated with major depressive disorder (MDD). It not only increases the risk of lifetime MDD, but it also aggravates its course. Among depressed patients, 20-30% of them experience treatment-resistance depression (TRD). We aimed to assess the association between childhood maltreatment, severity of depression in a unipolar TRD sample, and patient outcomes after one-year of follow-up.
Methods: Patients were recruited for a prospective cohort from the French network of TRD expert centers. Depressive symptom severity was assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Quick Inventory of Depressive Symptomatology self-report (QIDS-SR). Childhood maltreatment was evaluated with the Childhood Trauma Questionnaire (CTQ).
Results: In total, 256 patients filled in the CTQ at baseline between 2012 and 2019. At baseline, the MADRS score was associated with CTQ score (β = .185; p = .004). QIDS was also associated with CTQ scores (β = .27; p < .001). Regarding the different subtypes of childhood maltreatment, MADRS was associated with physical (β = .21; p = .005) and sexual abuse (β = .22; p = .002), while QIDS with physical abuse (β = .304; p < .001) and physical neglect (β = .254; p < .001). However, we did not find any significant association focusing on the other types of traumas. During a 1-year follow-up focusing on remission, CTQ scores (baseline) were less important in remittent patients [n = 38; CTQ score = 39.26 (9.68)] than in nonremittent ones [n = 92; CTQ score = 46.02 (17.53)] (p = .027). There was no significant difference among remitters and nonremitters based on trauma subtypes. At baseline, CTQ scores had a significant influence on remission at 1 year (χ2 (1) = 5.57; p < .05). We lost this influence adding MADRS scores at baseline in the model (p = .063).
Conclusion: We highlighted a significant association between the severity of depressive disorders and childhood maltreatment in the TRD population. Information about a history of childhood maltreatment helps in identifying individuals who could be less likely to go into remission after treatment.