Photoprintable Gelatin- graft -Poly(trimethylene carbonate) by Stereolithography for Tissue Engineering Applications - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Biomacromolecules Année : 2021

Photoprintable Gelatin- graft -Poly(trimethylene carbonate) by Stereolithography for Tissue Engineering Applications


The stereolithography process is a powerful additive manufacturing technology to fabricate scaffolds for regenerative medicine. Nevertheless, the quest for versatile inks allowing one to produce scaffolds with controlled properties is still unsatisfied. In this original article, we tackle this bottleneck by synthesizing a panel of photoprocessable hybrid copolymers composed of gelatin-graft-poly(trimethylene carbonate)s (Gel-g-PTMCn). We demonstrated that by changing the length of PTMC blocks grafted from gelatin, it is possible to tailor the final properties of the photofabricated objects. We reported here on the synthesis of Gel-g-PTMCn with various lengths of PTMC blocks grafted from gelatin using hydroxy and amino side groups of the constitutive amino acids. Then, the characterization of the resulting hybrid copolymers was fully investigated by quantitative NMR spectroscopy before rendering them photosensitive by methacrylation of the PTMC terminal groups. Homogeneous composition of the photocrosslinked hybrid polymers was demonstrated by EDX spectroscopy and electronic microscopy. To unravel the individual contribution of the PTMC moiety on the hybrid copolymer behavior, water absorption, contact angle measurements, and degradation studies were undertaken. Interestingly, the photocrosslinked materials immersed in water were examined using tensile experiments and displayed a large panel of behavior from hydrogel to elastomer-like depending on the PTMC/gel ratio. Moreover, the absence of cytotoxicity was conducted following the ISO 10993 assay. As a proof of concept, 3D porous objects were successfully fabricated using stereolithography. Those results validate the great potential of this panel of inks for tissue engineering and regenerative medicine.
Fichier principal
Vignette du fichier
Hybrid polymer based on grafted gelatin-poly(trimethylene carbonate) used in stereolithography towards tissue engineering applications.pdf (1.48 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03364511 , version 1 (05-11-2021)



Thomas Brossier, Gael Volpi, Jonaz Vasquez-Villegas, Noémie Petitjean, Olivier Guillaume, et al.. Photoprintable Gelatin- graft -Poly(trimethylene carbonate) by Stereolithography for Tissue Engineering Applications. Biomacromolecules, 2021, 22 (9), pp.3873-3883. ⟨10.1021/acs.biomac.1c00687⟩. ⟨hal-03364511⟩
98 Consultations
225 Téléchargements



Gmail Mastodon Facebook X LinkedIn More