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Article Dans Une Revue Chemical Communications Année : 2016

Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: novel CDK5 probes

Résumé

Novel 4,5-quinolimide-based fluorophores are more solvatochromic and red-shifted than known naphthalimide analogues. Conjugation of one of these fluorophores to a peptide derived from CDK5 kinase demonstrated its sensitivity for monitoring the interaction with its regulatory partner p25. Introduction of the quinolimide-labelled peptide into living glioblastoma cells probed the interaction with endogenous p25.
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Dates et versions

hal-03032093 , version 1 (14-02-2022)

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Juan González-Vera, Francisco Fueyo-González, Ibon Alkorta, Marion Peyressatre, May Morris, et al.. Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: novel CDK5 probes. Chemical Communications, 2016, 52 (62), pp.9652-9655. ⟨10.1039/c6cc04566a⟩. ⟨hal-03032093⟩
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