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Human antibody response to Anopheles gambiae saliva: an immuno-epidemiological biomarker to evaluate the efficacy of insecticide-treated nets in malaria vector control.

Abstract : For the fight against malaria, the World Health Organization (WHO) has emphasized the need for indicators to evaluate the efficacy of vector-control strategies. This study investigates a potential immunological marker, based on human antibody responses to Anopheles saliva, as a new indicator to evaluate the efficacy of insecticide-treated nets (ITNs). Parasitological, entomological, and immunological assessments were carried out in children and adults from a malaria-endemic region of Angola before and after the introduction of ITNs. Immunoglobulin G (IgG) levels to An. gambiae saliva were positively associated with the intensity of An. gambiae exposure and malaria infection. A significant decrease in the anti-saliva IgG response was observed after the introduction of ITNs, and this was associated with a drop in parasite load. This study represents the first stage in the development of a new indicator to evaluate the efficacy of malaria vector-control strategies, which could apply in other arthropod vector-borne diseases.
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https://hal.umontpellier.fr/hal-03021413
Contributeur : Anne Poinsignon <>
Soumis le : mardi 24 novembre 2020 - 12:15:06
Dernière modification le : jeudi 3 décembre 2020 - 17:00:02

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Papa Drame, Anne Poinsignon, Patrick Besnard, Jacques Le Mire, Maria Dos-Santos, et al.. Human antibody response to Anopheles gambiae saliva: an immuno-epidemiological biomarker to evaluate the efficacy of insecticide-treated nets in malaria vector control.. The American Journal of Tropical Medicine and Hygiene, 2010, 83 (1), pp.115-21. ⟨10.4269/ajtmh.2010.09-0684⟩. ⟨hal-03021413⟩

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