W. Zhao, D. G. Phinney, D. Bonnet, M. Dominici, and M. Krampera, Mesenchymal stem cell biodistribution, migration, and homing in vivo, Stem Cells Int, pp.10-12, 2014.

A. J. Friedenstein, K. V. Petrakova, A. I. Kurolesova, and G. P. Frolova, Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues, Transplantation, vol.6, pp.230-277, 1968.

S. P. Bruder, D. J. Fink, and A. I. Caplan, Mesenchymal stem cells in bone development, bone repair, and skeletal regenaration therapy, J Cell Biochem, vol.56, pp.283-94, 1994.

M. F. Pittenger, Multilineage potential of adult human mesenchymal stem cells, Science, vol.284, issue.5411, pp.143-150, 1999.

A. I. Caplan and S. P. Bruder, Mesenchymal stem cells: building blocks for molecular medicine in the 21st century, Trends Mol Med, vol.7, pp.259-64, 2001.

A. Tyndall, Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, Arthritis Res Ther, vol.9, p.301, 2005.

A. Uccelli, V. Pistoia, and L. Moretta, Mesenchymal stem cells: a new strategy for immunosuppression?, Trends Immunol, vol.28, pp.219-245, 2007.

F. E. Figueroa, F. Carrion, S. Villanueva, and M. Khoury, Mesenchymal stem cell treatment for autoimmune diseases: a critical review, Biol Res, vol.45, pp.269-77, 2012.

A. Augello, R. Tasso, S. M. Negrini, R. Cancedda, and G. Pennesi, Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis, Arthritis Rheum, vol.56, pp.1175-86, 2007.

E. Gonzalez-rey, Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis, Gut, vol.58, pp.929-968, 2009.

M. Rafei, E. Birman, K. Forner, and J. Galipeau, Allogeneic mesenchymal stem cells for treatment of experimental autoimmune encephalomyelitis, Mol Ther, vol.17, pp.1799-803, 2009.

E. Zappia, Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy, Blood, vol.106, p.1755, 2005.

M. Kurte, Intravenous administration of bone marrow-derived mesenchymal stem cells induces a switch from classical to atypical symptoms in experimental autoimmune encephalomyelitis, Stem Cells Int, vol.2015, pp.1-14, 2015.

M. Krampera, Mesenchymal stromal cell 'licensing': a multistep process, Leukemia, vol.25, issue.9, pp.1408-1422, 2011.

H. Cho, H. Bae, Y. C. Jung, and J. S. , Role of toll-like receptors on human adiposederived stromal cells, Stem Cells, vol.24, pp.2744-52, 2006.

S. L. Tomchuck, Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responses, Stem Cells, vol.26, pp.99-107, 2008.

C. Opitz, Toll-like receptor engagement enhances the immunosuppressive properties of human bone marrow-derived mesenchymal stem cells by inducing indoleamine-2,3-dioxygenase-1 via interferon-beta and protein kinase R, Stem Cells, vol.27, pp.909-919, 2009.

G. Raicevic, The source of human mesenchymal stromal cells influences their TLR profile as well as their functional properties, Cell Immunol, vol.270, pp.207-223, 2011.

G. Raicevic, Inflammation modifies the pattern and the function of tolllike receptors expressed by human mesenchymal stromal cells, Hum Immunol, vol.71, pp.235-279, 2010.

R. Romieu-mourez, Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype, J Immunol, vol.182, pp.7963-73, 2009.

S. Shirjang, B. Mansoori, S. Solali, M. F. Hagh, and K. Shamsasenjan, Toll-like receptors as a key regulator of mesenchymal stem cell function: an up-to-date review, Cell Immunol, vol.315, pp.1-10, 2017.

R. S. Waterman, S. L. Tomchuck, S. L. Henkle, and A. M. Betancourt, A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an immunosuppressive MSC2 phenotype, PLoS One, vol.5, p.10088, 2010.

M. L. Kapsenberg, C. M. Hilkens, E. A. Wierenga, and P. Kalinski, The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy, Clin Exp Allergy, vol.29, issue.2, pp.33-39, 1999.

G. Bakdash, S. P. Sittig, T. Van-dijk, C. G. Figdor, and I. De-vries, The nature of activatory and tolerogenic dendritic cell-derived signal II, Front Immunol, vol.4, p.53, 2013.

A. Sica, M. Erreni, P. Allavena, and C. Porta, Macrophage polarization in pathology, Cell Mol Life Sci, 2015.

A. M. Vega-letter, Differential TLR activation of murine mesenchymal stem cells generates distinct immunomodulatory effects in EAE, Stem Cell Res Ther, vol.7, p.150, 2016.

K. J. Livak and T. D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method, Methods, vol.25, pp.402-410, 2001.

P. Fuenzalida, Toll-like receptor 3 pre-conditioning increases the therapeutic efficacy of umbilical cord mesenchymal stromal cells in a dextran sulfate sodium-induced colitis model, Cytotherapy, vol.18, pp.630-671, 2016.

F. Liotta, Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling, Stem Cells, vol.26, pp.279-89, 2008.

C. Bouffi, C. Bony, G. Courties, C. Jorgensen, and D. Noël, IL-6-dependent PGE2 secretion by mesenchymal stem cells inhibits local inflammation in experimental arthritis, PLoS One, vol.5, p.14247, 2010.

I. Rashedi, A. Gómez-aristizábal, X. H. Wang, S. Viswanathan, and A. Keating, TLR3 or TLR4 activation enhances mesenchymal stromal cell-mediated Treg induction via Notch signaling, Stem Cells, vol.35, pp.265-75, 2017.

T. Lawrence and G. Natoli, Transcriptional regulation of macrophage polarization: enabling diversity with identity, Nat Rev Immunol, vol.11, p.750, 2011.

D. Ruffell, A CREB-C/EBP? cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair, Proc Natl Acad Sci U S A, vol.106, pp.17475-80, 2009.

Y. C. Liu, X. B. Zou, Y. F. Chai, and Y. M. Yao, Macrophage polarization in inflammatory diseases, Int J Biol Sci, vol.10, pp.520-529, 2014.

Y. Liao, W. Du, Y. Hu, F. Li, Y. Ma et al., CREB/Wnt10b mediates the effect of COX-2 on promoting BMP9-induced osteogenic differentiation via reducing adipogenic differentiation in mesenchymal stem cells, J Cell Biochem, vol.120, issue.6, pp.9572-87, 2018.

S. Akira and K. Takeda, Toll-like receptor signaling, Nat Rev Immunol, vol.4, issue.7, pp.499-511, 2004.

R. S. Waterman, Anti-inflammatory mesenchymal stem cells (MSC2) attenuate symptoms of painful diabetic peripheral neuropathy, Stem Cells Transl Med, vol.1, pp.557-65, 2012.

C. Xu, MiR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2, J Biol Chem, vol.288, pp.11074-11083, 2013.

G. Ren, Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide, Cell Stem Cell, vol.2, pp.141-50, 2008.

K. D. Taganov, M. P. Boldin, K. Chang, and D. Baltimore, NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses, Proc Natl Acad Sci, vol.103, issue.33, pp.12481-12487, 2006.

D. Ti, H. Hao, C. Tong, J. Liu, L. Dong et al., LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b, J Transl Med, vol.13, issue.1, 2015.

L. Huang, Y. Liu, and L. Wang, Down-regulation of miR-301a suppresses proinflammatory cytokines in Toll-like receptor-triggered macrophages, Immunology, vol.140, issue.3, pp.314-336, 2013.

J. Abdi, I. Rashedi, and A. Keating, Concise review: TLR pathway-miRNA interplay in mesenchymal stromal cells: regulatory roles and therapeutic directions, Stem Cells, vol.36, pp.1655-62, 2018.

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