Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases - Université de Montpellier Accéder directement au contenu
Article Dans Une Revue Biochemical Pharmacology Année : 2019

Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases

Résumé

Over the past years, through in vitro studies and unique animal models, biologists and clinicians have demonstrated that cellular senescence is at the root of numerous age-related chronic diseases including osteoarthritis and osteoporosis. This non-proliferative cellular syndrome can modify other surrounding tissue-resident cells through the establishment of a deleterious catabolic and inflammatory microenvironment. Targeting these deleterious cells through local or systemic seno-therapeutic agent delivery in pre-clinical models improves dramatically clinical signs and extends health span. In this review, we will summarize the current knowledge on cellular senescence, list the different strategies for identifying seno-suppressive therapeutic agents and their translations to rheumatic diseases.
Fichier principal
Vignette du fichier
IRMB_77_p52_1-s2.0-S0006295219301030-am.pdf (885.53 Ko) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-02877478 , version 1 (25-11-2020)

Licence

Identifiants

Citer

Yassin Tachikart, Olivier Malaise, Marcus Mumme, Christian Jorgensen, Jean-Marc Brondello. Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases. Biochemical Pharmacology, 2019, 165, pp.126-133. ⟨10.1016/j.bcp.2019.03.017⟩. ⟨hal-02877478⟩
39 Consultations
114 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More