Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Better Collaterals Are Independently Associated With Post-Thrombolysis Recanalization Before Thrombectomy

Abstract : Background and Purpose- In acute stroke patients with large vessel occlusion, the goal of intravenous thrombolysis (IVT) is to achieve early recanalization (ER). Apart from occlusion site and thrombus length, predictors of early post-IVT recanalization are poorly known. Better collaterals might also facilitate ER, for instance, by improving delivery of the thrombolytic agent to both ends of the thrombus. In this proof-of-concept study, we tested the hypothesis that good collaterals independently predict post-IVT recanalization before thrombectomy. Methods- Patients from the registries of 6 French stroke centers with the following criteria were included: (1) acute stroke with large vessel occlusion treated with IVT and referred for thrombectomy between May 2015 and March 2017; (2) pre-IVT brain magnetic resonance imaging, including diffusion-weighted imaging, T2*, MR angiography, and dynamic susceptibility contrast perfusion-weighted imaging; and (3) ER evaluated ≤3 hours from IVT start on either first angiographic run or noninvasive imaging. A collateral flow map derived from perfusion-weighted imaging source data was automatically generated, replicating a previously validated method. Thrombus length was measured on T2*-based susceptibility vessel sign. Results- Of 224 eligible patients, 37 (16%) experienced ER. ER occurred in 10 of 83 (12%), 17 of 116 (15%), and 10 of 25 (40%) patients with poor/moderate, good, and excellent collaterals, respectively. In multivariable analysis, better collaterals were independently associated with ER ( P=0.029), together with shorter thrombus ( P<0.001) and more distal occlusion site ( P=0.010). Conclusions- In our sample of patients with stroke imaged with perfusion-weighted imaging before IVT and intended for thrombectomy, better collaterals were independently associated with post-IVT recanalization, supporting our hypothesis. These findings strengthen the idea that advanced imaging may play a key role for personalized medicine in identifying patients with large vessel occlusion most likely to benefit from IVT in the thrombectomy era.
Liste complète des métadonnées

https://hal.umontpellier.fr/hal-02872182
Contributeur : Nathalie Salvy-Cordoba <>
Soumis le : mercredi 17 juin 2020 - 16:05:09
Dernière modification le : jeudi 15 avril 2021 - 15:08:09

Lien texte intégral

Identifiants

Citation

Pierre Seners, Pauline Roca, Laurence Legrand, Guillaume Turc, Jean-Philippe Cottier, et al.. Better Collaterals Are Independently Associated With Post-Thrombolysis Recanalization Before Thrombectomy. Stroke, American Heart Association, 2019, 50 (4), pp.867-872. ⟨10.1161/STROKEAHA.118.022815⟩. ⟨hal-02872182⟩

Partager

Métriques

Consultations de la notice

73