Tyrosine phosphorylation and Ras activation is required for hydrogen peroxide-mediated Raf-1 kinase activation, Mol Cell Biochem, vol.317, pp.121-129, 2008. ,
Guide to Receptors and Channels (GRAC), 4th edn, Br J Pharmacol, vol.158, pp.1-254, 2009. ,
Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress, Biochimie, vol.89, pp.73-82, 2007. ,
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines, Endocrinology, vol.130, pp.167-178, 1992. ,
Rapid activation and nuclear translocation of mitogen-activated protein kinases in response to physiological concentration of glucose in the MIN6 pancreatic ß cell line, J Biol Chem, vol.273, pp.15507-15513, 1998. ,
Protection of pancreatic beta-cells: is it feasible?, Nutr Metab Cardiovasc Dis, vol.18, pp.74-83, 2008. ,
Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells, Diabetes, vol.52, pp.974-983, 2003. ,
Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway, Int J Biochem Cell Biol, vol.41, pp.1284-1295, 2009. ,
, , 2007.
, Resveratrol enhances insulin secretion by blocking K(ATP) and K(V) channels of beta cells, Eur J Pharmacol, vol.568, pp.269-277
, , 2002.
, Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial, Lancet, vol.359, pp.2072-2077
, , 2005.
, Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas, Pharmacol Res, vol.51, pp.117-123
ERK1/2 control phosphorylation and protein level of cAMP-responsive element-binding protein: a key role in glucose-mediated pancreatic beta-cell survival, Diabetes, vol.55, pp.2220-2230, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00201283
Glucagon promotes cAMP-response element-binding protein phosphorylation via activation of ERK1/2 in MIN6 cell line and isolated islets of Langerhans, J Biol Chem, vol.279, pp.20345-20355, 2004. ,
Ellenberg and Rifkin's Diabetis Mellitus, 5th edn, pp.29-48, 1996. ,
Free radicals in the physiological control of cell function, Physiol Rev, vol.82, pp.47-95, 2002. ,
, , 2003.
, Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?, Diabetes, vol.52, pp.1-8
Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1, J Biol Chem, vol.270, pp.7882-7889, 1995. ,
Pharmacological manipulation of Ins(1,4,5)P3 signaling mimics preconditioning in rabbit heart, Am J Physiol, vol.277, pp.2458-2469, 1999. ,
Shortcomings of current models of glucose-induced insulin secretion, Diabetes Obes Metab, vol.11, pp.168-179, 2009. ,
Effects of flavonoids on insulin secretion and 45 Ca 2+ handling in rat islets of Langerhans, J Endocrinol, vol.107, pp.1-8, 1985. ,
, , 2008.
, Reactive oxygen species-mediated pancreatic beta-cell death is regulated by interactions between stress-activated protein kinases, p38 and c-Jun N-terminal kinase, and mitogen-activated protein kinase phosphatases, Endocrinology, vol.149, pp.1654-1665
Dominant role of sarcoendoplasmic reticulum Ca 2+ -ATPase pump in Ca 2+ homeostasis and exocytosis in rat pancreatic beta-cells, Endocrinology, vol.147, pp.1396-1407, 2006. ,
Anti-apoptotic effect of quercetin: intervention in the JNK-and ERK-mediated apoptotic pathways, Kidney Int, vol.58, pp.1078-1087, 2000. ,
, , 2008.
, Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival, FASEB J, vol.22, pp.954-965
Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity, Diabetes, vol.48, pp.2398-2406, 1999. ,
Oxidative stress and the JNK pathway in diabetes, Curr Diabetes Rev, vol.1, pp.65-72, 2005. ,
Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance, Int J Biochem Cell Biol, vol.37, pp.1595-1608, 2005. ,
Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion, Proc Natl Acad Sci U S A, vol.94, pp.5599-5604, 1997. ,
Underlying mechanism of quercetin-induced cell death in human glioma cells, Neurochem Res, vol.33, pp.971-979, 2008. ,
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin, Diabetes Prevention Program Research Group, vol.346, pp.393-403, 2002. ,
Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program, Diabetes Prevention Program Research Group, vol.54, pp.1150-1156, 2005. ,
Identification and subcellular characterization of protein kinase C isoforms in insulinoma ß-cells and whole islets, Endocrinology, vol.135, pp.881-886, 1994. ,
, , 2009.
, Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin-induced disturbance of hepatic gene expression in mice, Mol Nutr Food Res, vol.53, pp.859-868
Method for the isolation of intact islets of Langerhans from the rat pancreas, Diabetes, vol.16, pp.35-39, 1967. ,
Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine, Cancer Res, vol.68, pp.946-955, 2008. ,
Oxidative stress: the vulnerable beta-cell, Biochem Soc Trans, vol.36, pp.343-347, 2008. ,
The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress, Biochem Soc Trans, vol.36, pp.930-934, 2008. ,
Extracellularly regulated kinases 1/2 (p44/42 mitogen-activated protein kinases) phosphorylate synapsin I and regulate insulin secretion in the MIN6 beta-cell line and islets of Langerhans, Endocrinology, vol.146, pp.643-654, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-00017043
Reactive oxygen species-induced activation of the MAP kinase signaling pathways, Antioxid Redox Signal, vol.8, pp.1775-1789, 2006. ,
Quercetin allievates oxidative stress in streptozotocin-induced diabetic rats, Phytother Res, vol.18, pp.123-127, 2004. ,
Curcumin prevents streptozotocin-induced islet damage by scavenging free radicals: a prophylactic and protective role, Eur J Pharmacol, vol.577, pp.183-191, 2007. ,
Role of receptor and nonreceptor protein tyrosine kinases in H 2O2-induced PKB and ERK1/2 signaling, Cell Biochem Biophys, vol.47, pp.1-10, 2007. ,
The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells, Carcinogenesis, vol.25, pp.647-659, 2004. ,
Inhibition of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase by flavonoids: a quantitative structure-activity relationship study, IUBMB Life, vol.60, pp.853-858, 2008. ,
Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats, Biomed Pharmacother, vol.62, pp.598-605, 2008. ,
Neuroprotective effect of N-acetylcysteine in neurons exposed to arachidonic acid during simulated ischemia in vitro, Pharmacol Rep, vol.61, pp.743-750, 2009. ,
Glucolipotoxicity: fuel excess and beta-cell dysfunction, Endocr Rev, vol.29, pp.351-366, 2008. ,
Dose-dependent cysteine-mediated protection of insulin-producing cells from damage by hydrogen peroxide, Biochem Pharmacol, vol.63, pp.1297-1304, 2002. ,
, , 2007.
, Antioxidative and prooxidative effects of quercetin on A549 cells, Cell Biol Int, vol.31, pp.1245-1250
Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells, Biochem Biophys Res Commun, vol.300, pp.216-222, 2003. ,
Ten-year follow-up of subjects with impaired glucose tolerance: prevention of diabetes by tolbutamide and diet regulation, Diabetes, vol.29, pp.41-49, 1980. ,
Dietary polyphenols and the prevention of diseases, Crit Rev Food Sci Nutr, vol.45, pp.287-306, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-00294418
Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid, J Cell Biochem, vol.104, pp.1232-1243, 2008. ,
Amelioration of the beta-cell dysfunction in diabetic APA hamsters by antioxidants and AGE inhibitor treatments, Diabetes Metab Res Rev, vol.20, pp.211-218, 2004. ,
Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants, Proc Natl Acad Sci U S A, vol.96, pp.10857-10862, 1999. ,
Sulfonylureas enhance exocytosis from pancreatic beta-cells by a mechanism that does not involve direct activation of protein kinase C, Diabetes, vol.47, pp.1722-1726, 1998. ,
Antidiabetic effects of quercetin in streptozocin-induced diabetic rats, Comp Biochem Physiol C, vol.135, pp.357-364, 2003. ,
Inhibition of c-Jun N-terminal kinase ameliorates apoptosis induced by hydrogen peroxide in the kidney tubule epithelial cells (NRK-52E), Nephron, vol.91, pp.142-147, 2002. ,
, , 2008.
, Glibenclamide activates translation in rat pancreatic beta cells through calcium-dependent mTOR, PKA and MEK signalling pathways, Diabetologia, vol.51, pp.1202-1212
Glucose activates the multifunctional calcium/calmodulin dependent protein kinase II in isolated rat pancreatic islets, J Biol Chem, vol.269, pp.4947-4952, 1994. ,
Flavonoids: antioxidants or signalling molecules?, Free Radic Biol Med, vol.36, pp.838-849, 2004. ,
Puerarin protects rat pancreatic islets from damage by hydrogen peroxide, Eur J Pharmacol, vol.529, pp.1-7, 2006. ,
Insulin secretion and cyclooxygenase enzyme inhibition by cabernet sauvignon grape skin compounds, J Agric Food Chem, vol.52, pp.228-233, 2004. ,