Dystrophin: The protein product of the Duchenne muscular dystrophy locus, Cell, vol.51, pp.919-928, 1987. ,
The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein, Cell, vol.53, pp.219-228, 1988. ,
Dystrophin and mutations: One gene, several proteins, multiple phenotypes, Lancet Neurol, vol.2, pp.731-740, 2003. ,
Current treatment of adult Duchenne muscular dystrophy, Biochim Biophys Acta, vol.1772, pp.229-237, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00562721
The heart in human dystrophinopathies, Cardiology, vol.99, pp.1-19, 2003. ,
High incidence of electrocardiogram abnormalities in young patients with Duchenne muscular dystrophy, Pediatr Neurol, vol.39, pp.399-403, 2008. ,
Ventricular arrhythmia in Duchenne muscular dystrophy: Prevalence, significance and prognosis, Neuromuscul Disord, vol.3, pp.201-206, 1993. ,
Re-examination of the electrocardiogram in boys with Duchenne muscular dystrophy and correlation with its dilated cardiomyopathy, Am J Cardiol, vol.103, pp.262-265, 2009. ,
Mechanisms of stretch-induced muscle damage in normal and dystrophic muscle: Role of ionic changes, J Physiol, vol.567, pp.723-735, 2005. ,
Stretch-activated channels in stretch-induced muscle damage: Role in muscular dystrophy, Clin Exp Pharmacol Physiol, vol.31, pp.551-556, 2004. ,
Dystrophic cardiomyopathy: Amplification of cellular damage by Ca2+ signalling and reactive oxygen speciesgenerating pathways, Cardiovasc Res, vol.77, pp.766-773, 2008. ,
Stretch-activated channels in the heart: Contributions to length dependence and to cardiomyopathy, Prog Biophys Mol Biol, vol.97, pp.232-249, 2008. ,
Intracellular calcium handling in ventricular myocytes from mdx mice, Am J Physiol Heart Circ Physiol, vol.292, pp.846-855, 2007. ,
Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism, Proc Natl Acad Sci, vol.106, pp.19023-19028, 2009. ,
Dominantnegative inhibition of Ca2+ influx via TRPV2 ameliorates muscular dystrophy in animal models, Hum Mol Genet, vol.18, pp.824-834, 2009. ,
The role of reactive oxygen species in the hearts of dystrophin-deficient mdx mice, Am J Physiol Heart Circ Physiol, vol.293, pp.1969-1977, 2007. ,
Metabolic and signaling alterations in dystrophin-deficient hearts precede overt cardiomyopathy, J Mol Cell Cardiol, vol.43, pp.119-129, 2007. ,
Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle, Nat Med, vol.3, pp.325-330, 2009. ,
Decreased myocardial nNOS, increased iNOS and abnormal ECGs in mouse models of Duchenne muscular dystrophy, J Mol Cell Cardiol, vol.31, pp.1857-1862, 1999. ,
Remodeling of ryanodine receptor complex causes "leaky" channels: A molecular mechanism for decreased exercise capacity, Proc Natl Acad Sci, vol.105, pp.2198-2202, 2008. ,
Dystrophin-deficient cardiomyocytes are abnormally vulnerable to mechanical stress-induced contractile failure and injury, FASEB J, vol.15, pp.1655-1657, 2001. ,
Calcium sparks: Elementary events underlying excitation-contraction coupling in heart muscle, Science, vol.262, pp.740-744, 1993. ,
Calcium sparks, Physiol Rev, vol.88, pp.1491-1545, 2008. ,
Heart rate variability in mice: A theoretical and practical guide, Exp Physiol, vol.93, pp.83-94, 2008. ,
Sotalol: An important new antiarrhythmic, Am Heart J, vol.137, pp.388-409, 1999. ,
Frequency-dependent and proarrhythmogenic effects of FK-506 in rat ventricular cells, Am J Physiol Heart Circ Physiol, vol.288, pp.778-786, 2005. ,
Na/Ca exchange in heart failure: Contractile dysfunction and arrhythmogenesis, Ann N Y Acad Sci, vol.976, pp.454-465, 2002. ,
FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death, Cell, vol.113, pp.829-840, 2003. ,
Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias, Proc Natl Acad Sci, vol.103, pp.7906-7910, 2006. ,
Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure, Proc Natl Acad Sci, vol.102, pp.9607-9612, 2005. ,
Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2, Science, vol.304, pp.292-296, 2004. ,
Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts: Role of phosphatases and response to isoproterenol, J Biol Chem, vol.278, pp.444-453, 2003. ,
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias, Cell, vol.123, pp.25-35, 2005. ,
PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts, Cell, vol.101, pp.365-376, 2000. ,
Regulation of the mammalian heart function by nitric oxide, Comp Biochem Physiol A Mol Integr Physiol, vol.142, pp.144-150, 2005. ,
Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation, Science, vol.279, pp.234-237, 1998. ,
Nitric oxide activates or inhibits skeletal muscle ryanodine receptors depending on its concentration, membrane potential and ligand binding, J Membr Biol, vol.173, pp.227-236, 2000. ,
Differential role of S-nitrosylation and the NO-cGMP-PKG pathway in cardiac contractility, Nitric Oxide, vol.18, pp.157-167, 2008. ,
Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy, Cell, vol.82, pp.743-752, 1995. ,
Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms, Nature, vol.416, pp.337-339, 2002. ,
Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes, Nat Cell Biol, vol.3, pp.867-873, 2001. ,
Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes, Proc Natl Acad Sci, vol.104, pp.20612-20617, 2007. ,
iNOS expression in dystrophinopathies can be reduced by somatic gene transfer of dystrophin or utrophin, Mol Med, vol.7, pp.355-364, 2001. ,
URL : https://hal.archives-ouvertes.fr/hal-01361966
Cardiomyopathy in dystrophin-deficient hearts is prevented by expression of a neuronal nitric oxide synthase transgene in the myocardium, Hum Mol Genet, vol.14, pp.1921-1933, 2005. ,
Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency, Proc Natl Acad Sci, vol.105, pp.7028-7033, 2008. ,
Challenges and opportunities in dystrophin-deficient cardiomyopathy gene therapy, Hum Mol Genet, vol.15, pp.253-261, 2006. ,
Dystrophic heart failure blocked by membrane sealant poloxamer, Nature, vol.436, pp.1025-1029, 2005. ,
QT dispersion in patients with Duchenne-type progressive muscular dystrophy, Am Heart J, vol.137, pp.672-677, 1999. ,
Cardiac involvement in Becker muscular dystrophy, Can J Cardiol, vol.24, pp.786-792, 2008. ,