J. S. Chamberlain, J. Metzger, and M. Reyes, Dystrophin-deficient mdx mice display a reduced life span and are susceptible to spontaneous rhabdomyosarcoma, FASEB J, vol.21, pp.2195-204, 2007.

K. Fernandez, Y. Serinagaoglu, and S. Hammond, Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts, Am J Pathol, vol.176, pp.416-450, 2010.

V. Hosur, A. Kavirayani, and J. Riefler, Dystrophin and dysferlin double mutant mice: a novel model for rhabdomyosarcoma, Cancer Genet, vol.205, pp.232-273, 2012.

W. M. Schmidt, M. H. Uddin, and S. Dysek, DNA damage, somatic aneuploidy, and malignant sarcoma susceptibility in muscular dystrophies, PLoS Genet, 2011.

A. Fanzani, E. Monti, and R. Donato, Muscular dystrophies share pathogenetic mechanisms with muscle sarcomas, Trends Mol Med, vol.19, pp.546-54, 2013.

H. C. Rossbach, A. Lacson, and N. H. Grana, Duchenne muscular dystrophy and concomitant metastatic alveolar rhabdomyosarcoma, J Pediatr Hematol Oncol, vol.21, pp.528-558, 1999.

Z. Jakab, I. Szegedi, and E. Balogh, Duchenne muscular dystrophy-rhabdomyosarcoma, ichthyosis vulgaris/acute monoblastic leukemia: association of rare genetic disorders and childhood malignant diseases, Med Pediatr Oncol, vol.39, pp.66-74, 2002.

H. Doddihal and R. Jalali, Medulloblastoma in a child with Duchenne muscular dystrophy, Childs Nerv Syst, vol.23, pp.595-602, 2007.

K. M. Johnston, S. Zoger, and M. Golabi, Neuroblastoma in Duchenne muscular dystrophy, Pediatrics, vol.78, pp.1170-1171, 1986.

D. N. Korones, M. R. Brown, and J. Palis, Liver function tests" are not always tests of liver function, Am J Hematol, vol.66, pp.46-54, 2001.

R. M. Saldanha, J. R. Gasparini, and L. S. Silva, Anesthesia for Duchenne muscular dystrophy patients: case reports, Rev Bras Anestesiol, vol.55, pp.445-454, 2005.

E. Svarch, A. Menendez, and A. Gonzalez, Duchenne muscular dystrophy and acute lymphoblastic leukaemia, Haematologia (Budap), vol.21, pp.123-127, 1988.

M. Van-den-akker, P. Northcott, and M. D. Taylor, Anaplastic medulloblastoma in a child with Duchenne muscular dystrophy, J Neurosurg Pediatr, vol.10, pp.21-25, 2012.

D. Blake, C. Gilliam, and D. Warburton, Possible clue for chromosomal assignment of the gene for facioscapulohumeral muscular dystrophy: a family with polyposis, Ann Neurol, vol.24, p.178, 1988.

D. Blake, R. Brown, and T. Gilliam, The second family with facioscapulo-humeral muscular dystrophy and familial polyposis coli, Neurology, vol.39, p.404, 1989.

V. Kazakov, D. Rudenko, and J. Schulev, Unusual association of FSHD and extramedullary thoracic tumour in the same patient: a case report, Acta Myol, vol.28, pp.76-85, 2009.

S. M. Gadalla, M. Lund, and R. M. Pfeiffer, Cancer risk among patients with myotonic muscular dystrophy, JAMA, vol.306, pp.2480-2486, 2011.

A. K. Win, P. G. Perattur, and J. S. Pulido, Increased cancer risks in myotonic dystrophy, Mayo Clin Proc, vol.87, pp.130-135, 2012.

J. C. De-greef, R. R. Frants, and S. M. Van-der-maarel, Epigenetic mechanisms of facioscapulohumeral muscular dystrophy, Mutat Res, vol.647, pp.94-102, 2008.

D. S. Cabianca and D. Gabellini, FSHD: copy number variations on the theme of muscular dystrophy, JCB, vol.191, pp.1049-60, 2010.

R. Tawil, Facioscapulohumeral muscular dystrophy, Neurotherapeutics, vol.5, pp.601-607, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00770764

J. C. De-greef, R. J. Lemmers, and B. G. Van-engelen, Common epigenetic changes of D4Z4 in contraction-dependent and contractionindependent FSHD, Hum Mutat, 2009.

M. Yoshimoto, C. Graham, and S. Chilton-macneill, Detailed cytogenetic and array analysis of pediatric primitive sarcomas reveals a recurrent CIC-DUX4 fusion gene event, Cancer Genet Cytogenet, vol.195, pp.1-11, 2010.

A. Italiano, Y. S. Sung, and L. Zhang, High prevalence of CIC fusion with doublehomeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas, Genes Chromosom Cancer, vol.51, pp.207-225, 2012.

C. Graham, S. Chilton-macneill, and M. Zielenska, The CIC-DUX4 fusion transcript is present in a subgroup of pediatric primitive round cell sarcomas, Hum Pathol, vol.43, pp.180-189, 2012.

M. Kawamura-saito, Y. Yamazaki, and K. Kaneko, Fusion between CIC and DUX4 upregulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation, Hum Mol Genet, vol.15, pp.2125-2162, 2006.

N. Sirvent, M. Trassard, and N. Ebran, Fusion of EWSR1 with the DUX4 facioscapulohumeral muscular dystrophy region resulting from t(4;22)(q35;q12) in a case of embryonal rhabdomyosarcoma, Cancer Genet Cytogenet, vol.195, pp.12-20, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00435710

A. N. Katargin, L. S. Pavlova, and F. L. Kisseljov, Hypermethylation of genomic 3.3-kb repeats is frequent event in HPV-positive cervical cancer, BMC Med Genomics, 2009.

K. Tsumagari, L. Qi, and K. Jackson, Epigenetics of a tandem DNA repeat: chromatin DNaseI sensitivity and opposite methylation changes in cancers, Nucleic Acids Res, 2008.

M. Richards, F. Coppee, and N. Thomas, Facioscapulohumeral muscular dystrophy (FSHD): an enigma unravelled?, Hum Genet, 2011.

S. M. Van-der-maarel, R. Tawil, and S. J. Tapscott, Facioscapulohumeral muscular dystrophy and DUX4: breaking the silence, Trends Mol Med, vol.17, pp.252-260, 2011.

A. Petrov, J. Allinne, and I. Pirozhkova, A nuclear matrix attachment site in the 4q35 locus has an enhancer-blocking activity in vivo: implications for the facio-scapulo-humeral dystrophy, Genome Res, vol.18, pp.39-45, 2008.

P. Dmitriev, A. Petrov, and E. Ansseau, The Kruppel-like factor 15 as a molecular link between myogenic factors and a chromosome 4q transcriptional enhancer implicated in facioscapulohumeral dystrophy, J Biol Chem, vol.286, pp.44620-44651, 2011.
URL : https://hal.archives-ouvertes.fr/hal-02540056

M. Barro, G. Carnac, and S. Flavier, Myoblasts from affected and non-affected FSHD muscles exhibit morphological 216 ª 2013 The Authors, John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. differentiation defects. J Cell Mol Med, vol.14, pp.275-89, 2010.

K. J. Livak and T. D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) Method, Methods, vol.25, pp.402-410, 2001.

P. Georgin and M. Gouet, Statistiques avec Excel, 2000.

P. Cahan, A. M. Ahmad, and H. Burke, List of lists-annotated (LOLA): a database for annotation and comparison of published microarray gene lists, Gene, vol.360, pp.78-82, 2005.

U. Mudunuri, C. A. Yi, and M. , bioDBnet: the biological database network, Bioinformatics, vol.25, pp.555-561, 2009.

S. T. Winokur, Y. W. Chen, and P. S. Masny, Expression profiling of FSHD muscle supports a defect in specific stages of myogenic differentiation, Hum Mol Genet, vol.12, pp.2895-907, 2003.

S. T. Winokur, K. Barrett, and J. H. Martin, Facioscapulohumeral muscular dystrophy (FSHD) myoblasts demonstrate increased susceptibility to oxidative stress, Neuromuscul Disord, vol.13, pp.322-355, 2003.

B. Celegato, D. Capitanio, and M. Pescatori, Parallel protein and transcript profiles of FSHD patient muscles correlate to the D4Z4 arrangement and reveal a common impairment of slow to fast fibre differentiation and a general deregulation of MyoD-dependent genes, Proteomics, vol.6, pp.5303-5324, 2006.

R. Morosetti, M. Mirabella, and C. Gliubizzi, Isolation and characterization of mesoangioblasts from facioscapulohumeral muscular dystrophy muscle biopsies, Stem Cells, vol.25, pp.3173-82, 2007.

R. J. Osborne, S. Welle, and S. L. Venance, Expression profile of FSHD supports a link between retinal vasculopathy and muscular dystrophy, Neurology, vol.68, pp.569-77, 2007.

S. Cheli, S. Francois, and B. Bodega, Expression profiling of FSHD-1 and FSHD-2 cells during myogenic differentiation evidences common and distinctive gene dysregulation patterns, PLoS ONE, 2011.

F. Rahimov, O. D. King, and D. G. Leung, Transcriptional profiling in facioscapulohumeral muscular dystrophy to identify candidate biomarkers, Proc Natl Acad Sci USA, vol.109, pp.16234-16243, 2012.

Y. Lu, Y. Yi, and P. Liu, Common human cancer genes discovered by integrated geneexpression analysis, PLoS ONE, vol.2, p.1149, 2007.

N. Fankhauser, I. Cima, and P. Wild, Identification of a gene expression signature common to distinct cancer pathways, Cancer Inform, vol.11, pp.139-185, 2012.

P. A. Futreal, L. Coin, and M. Marshall, A census of human cancer genes, Nat Rev Cancer, vol.4, pp.177-83, 2004.

C. F. Basil, Y. Zhao, and K. Zavaglia, Common cancer biomarkers, Cancer Res, vol.66, pp.2953-61, 2006.

N. P. Palmer, P. R. Schmid, and B. Berger, A gene expression profile of stem cell pluripotentiality and differentiation is conserved across diverse solid and hematopoietic cancers, Genome Biol, vol.13, p.71, 2012.

H. A. Hirsch, D. Iliopoulos, and A. Joshi, A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases, Cancer Cell, vol.17, pp.348-61, 2010.

D. R. Rhodes, J. Yu, and K. Shanker, Largescale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression, Proc Natl Acad Sci USA, vol.101, pp.9309-9323, 2004.

J. Khan, J. S. Wei, and M. Ringner, Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks, Nat Med, vol.7, pp.673-682, 2001.

B. T. Greer and J. Khan, Diagnostic classification of cancer using DNA microarrays and artificial intelligence, Ann N Y Acad Sci, vol.1020, pp.49-66, 2004.

J. Mitsui, Y. Takahashi, and J. Goto, Mechanisms of genomic instabilities underlying two common fragile-site-associated loci, PARK2 and DMD, in germ cell and cancer cell lines, Am J Hum Genet, vol.87, pp.75-89, 2010.

R. J. Lemmers, P. J. Van-der-vliet, and R. Klooster, A unifying genetic model for facioscapulohumeral muscular dystrophy, Science, vol.329, pp.1650-1653, 2010.

D. Gabellini, D. 'antona, G. Moggio, and M. , Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1, Nature, vol.439, pp.973-980, 2006.

L. Davidovic, S. Sacconi, and E. G. Bechara, Alteration of expression of muscle specific isoforms of the fragile X related protein 1 (FXR1P) in facioscapulohumeral muscular dystrophy patients, J Med Genet, vol.45, pp.679-85, 2008.

M. Pistoni, L. Shiue, and M. S. Cline, Rbfox1 downregulation and altered calpain 3 splicing by FRG1 in a mouse model of Facioscapulohumeral muscular dystrophy (FSHD)

, PLoS Genet, 2013.

S. Van-koningsbruggen, K. R. Straasheijm, and E. Sterrenburg, FRG1P-mediated aggregation of proteins involved in pre-mRNA processing, Chromosoma, vol.116, pp.53-64, 2007.

J. P. Venables, Aberrant and alternative splicing in cancer, Cancer Res, vol.64, pp.7647-54, 2004.

N. A. Faustino and T. A. Cooper, Pre-mRNA splicing and human disease, Genes Dev, vol.17, pp.419-456, 2003.

S. Hino, S. Kondo, and H. Sekiya, Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type

, Hum Mol Genet, vol.16, pp.2834-2877, 2007.

C. M. Mueller, J. E. Hilbert, and W. Martens, Hypothesis: neoplasms in myotonic dystrophy, Cancer Causes Control, vol.20, pp.2009-2029, 2009.

A. Zemtsov, Association between basal, squamous cell carcinomas, dysplastic nevi and myotonic muscular dystrophy indicates an important role of RNA-binding proteins in development of human skin cancer, Arch Dermatol Res, vol.302, pp.169-70, 2010.

Y. D. Krom, P. E. Thijssen, and J. M. Young, Intrinsic epigenetic regulation of the D4Z4 macrosatellite repeat in a transgenic mouse model for FSHD, PLoS Genet, 2013.

S. N. Pandey, J. Cabotage, and R. Shi, Conditional over-expression of PITX1 causes skeletal muscle dystrophy in mice, Biol Open, vol.1, pp.629-668, 2013.

M. Gomes-pereira, T. A. Cooper, and G. Gourdon, Myotonic dystrophy mouse models: towards rational therapy development, Trends Mol Med, vol.17, pp.506-523, 2011.

T. Ito, R. Ogawa, and A. Uezumi, Imatinib attenuates severe mouse dystrophy and inhibits proliferation and fibrosis-marker expression in muscle mesenchymal progenitors, Neuromuscul Disord, vol.23, pp.349-56, 2013.

O. M. Dorchies, J. Reutenauer-patte, and E. Dahmane, The anticancer drug tamoxifen counteracts the pathology in a mouse model of duchenne muscular dystrophy, Am J Pathol, vol.182, pp.485-504, 2013.

, The Authors, Journal of Cellular and Molecular Medicine, 2013.