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Investigation of host factors possibly enhancing the emergence of the chondroitin sulfate A-binding phenotype in Plasmodium falciparum

Abstract : In malaria endemic areas, regardless of immunity acquired during lifelong exposure to malaria, pregnant women become susceptible to Plasmodium falciparum infections. Malaria during pregnancy is associated with a massive sequestration of infected erythrocytes in the placenta and the emergence of a unique parasite-derived adhesive molecule (encoded by var2CSA) that binds to chondroitin sulfate A (CSA). How P. falciparum achieves the timely expression of the CSA ligand in pregnant women remains puzzling. We investigated whether host serum-specific factors present only during pregnancy may induce var2CSA expression. Our panel of experiments did not reveal significant changes in var2CSA levels and CSA-binding capacity.
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https://hal.umontpellier.fr/hal-02507431
Contributeur : Nathalie Salvy-Cordoba <>
Soumis le : vendredi 13 mars 2020 - 10:46:30
Dernière modification le : mercredi 18 mars 2020 - 01:34:44

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Marta Nunes, Yvon Sterkers, Benoit Gamain, Artur Scherf. Investigation of host factors possibly enhancing the emergence of the chondroitin sulfate A-binding phenotype in Plasmodium falciparum. Microbes and Infection, Elsevier, 2008, 10 (8), pp.928-932. ⟨10.1016/j.micinf.2008.05.006⟩. ⟨hal-02507431⟩

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