Improved scoring of functional groups from gene expression data by decorrelating GO graph structure, Bioinformatics, vol.22, pp.1600-1607, 2006. ,
HTSeq-a Python framework to work with high-throughput sequencing data, Bioinformatics, vol.31, pp.166-1669, 2015. ,
The mGluR theory of fragile X mental retardation, Trends Neurosci, vol.27, pp.370-377, 2004. ,
The pathophysiology of fragile X (and what it teaches us about synapses), Annu. Rev. Neurosci, vol.35, pp.417-443, 2012. ,
Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice, Neuron, vol.76, pp.325-337, 2012. ,
PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons, J. Neurosci, vol.35, pp.4113-4130, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01883480
Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model, J. Med. Genet, vol.46, pp.94-102, 2009. ,
Targeting the endocannabinoid system in the treatment of fragile X syndrome, Nat. Med, vol.19, pp.603-607, 2013. ,
Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus, J. Neurosci, vol.15, pp.5088-5097, 1995. ,
Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits, Proc. Natl. Acad. Sci. U.S.A, vol.94, pp.5401-5404, 1997. ,
Altered neuronal and circuit excitability in Fragile X Syndrome, Neuron, vol.87, pp.699-715, 2015. ,
FMRP RNA targets: identification and validation, Genes Brain Behav, vol.4, pp.341-349, 2005. ,
FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism, Cell, vol.146, pp.247-261, 2011. ,
Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity, J. Neurosci, vol.21, pp.6993-7000, 2001. ,
Correction of fragile X syndrome in mice, Neuron, vol.56, pp.955-962, 2007. ,
Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models, Front. Cell. Neurosci, vol.8, p.30, 2014. ,
Bioconductor: open software development for computational biology and bioinformatics, Genome Biol, vol.5, p.80, 2004. ,
Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes, Cell Rep, vol.9, pp.1742-1755, 2014. ,
The trouble with spines in fragile X syndrome: density, maturity and plasticity, Neuroscience, vol.251, pp.120-128, 2013. ,
A translational profiling approach for the molecular characterization of CNS cell types, Cell, vol.135, pp.738-748, 2008. ,
Dendritic spines: structure, dynamics and regulation, Nat. Rev. Neurosci, vol.2, pp.880-888, 2001. ,
Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depression, Neuron, vol.51, pp.441-454, 2006. ,
Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome, J. Neurosci, vol.28, pp.7847-7862, 2008. ,
Altered synaptic plasticity in a mouse model of fragile X mental retardation, Proc. Natl. Acad. Sci. U.S.A, vol.99, pp.7746-7750, 2002. ,
Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: a quantitative examination, Am. J. Med. Genet, vol.98, pp.161-167, 2001. ,
Diversity of neuropsin (KLK8)-dependent synaptic associativity in the hippocampal pyramidal neuron, J. Physiol, vol.589, pp.3559-3573, 2011. ,
The Fragile X mental retardation protein regulates matrix metalloproteinase 9 mRNA at synapses, J. Neurosci, vol.33, pp.18234-18241, 2013. ,
The autistic neuron: troubled translation?, Cell, vol.135, pp.401-406, 2008. ,
RNA Secondary structure modulates FMRP's Bi-functional role in the MicroRNA pathway, Int. J. Mol. Sci, vol.17, p.985, 2016. ,
TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions, Genome Biol, vol.14, p.36, 2013. ,
Neuropsin regulates an early phase of schaffer-collateral longterm potentiation in the murine hippocampus, Eur. J. Neurosci, vol.12, pp.1479-1486, 2000. ,
Toward fulfilling the promise of molecular medicine in fragile X syndrome, Annu. Rev. Med, vol.62, pp.411-429, 2011. ,
Fast gapped-read alignment with Bowtie 2, Nat. Methods, vol.9, pp.357-359, 2012. ,
Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome, J. Neurosci, vol.27, pp.10685-10694, 2007. ,
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2, Genome Biol, vol.15, p.550, 2014. ,
Fragile X spectrum disorders, Intractable Rare Dis. Res, vol.3, pp.134-146, 2014. ,
Distribution of Wfs1 protein in the central nervous system of the mouse and its relation to clinical symptoms of the Wolfram syndrome, J. Comp. Neurol, vol.509, pp.642-660, 2008. ,
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain, Nat. Neurosci, vol.13, pp.133-140, 2010. ,
NMDA-dependent proteolysis of presynaptic adhesion molecule L1 in the hippocampus by neuropsin, J. Neurosci, vol.23, pp.7727-7736, 2003. ,
Gene expression changes in the MAPK pathway in both Fragile, X., and Down syndrome human neural progenitor cells, Am. J. Stem Cells, vol.1, pp.154-162, 2012. ,
STDP and mental retardation: dysregulation of dendritic excitability in fragile X Syndrome, Front. Synaptic Neurosci, vol.2, p.10, 2010. ,
Increased threshold for spike-timing-dependent plasticity is caused by unreliable calcium signaling in mice lacking fragile X gene FMR1, Neuron, vol.54, pp.627-638, 2007. ,
Blockade of neuropsin, a serine protease, ameliorates kindling epilepsy, Eur. J. Neurosci, vol.10, pp.760-764, 1998. ,
Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome, Neuron, vol.77, pp.243-250, 2013. ,
Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome, J. Neurosci, vol.30, pp.15616-15627, 2010. ,
The small pyramidal neuron of the rat cerebral cortex. The synapses upon dendritic spines, Z Zellforsch Mikrosk Anat, vol.100, pp.487-506, 1969. ,
Absence of expression of the FMR-1 gene in fragile X syndrome, Cell, vol.66, pp.817-822, 1991. ,
On the function of dendritic filopodia, Rev. Neurol, vol.33, pp.1158-1166, 2001. ,
Anatomical and molecular characterization of dopamine D1 receptor-expressing neurons of the mouse CA1 dorsal hippocampus, Brain Struct. Funct, vol.4, pp.1897-1911, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01936375
R-Baclofen reverses a social behavior deficit and elevated protein synthesis in a mouse model of fragile X Syndrome, Int. J. Neuropsychopharmacol, vol.28, p.18, 2015. ,
Postadolescent changes in regional cerebral protein synthesis: an in vivo study in the FMR1 null mouse, J. Neurosci, vol.25, pp.5087-5095, 2005. ,
Impaired cognitive discrimination and discoordination of coupled theta-gamma oscillations in Fmr1 knockout mice, Neurobiol. Dis, vol.88, pp.125-138, 2016. ,
Cell-type-specific isolation of ribosome-associated mRNA from complex tissues, Proc. Natl. Acad. Sci. U.S.A, vol.106, pp.13939-13944, 2009. ,
Heterogeneous ribosomes preferentially translate distinct subpools of mRNAs genome-wide, Mol. Cell, vol.67, pp.71-83, 2017. ,
Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile X syndrome in a mouse model, J. Neurosci, vol.34, pp.9867-9879, 2014. ,
Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons, Proc. Natl. Acad. Sci. U.S.A, vol.113, pp.3619-3628, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01594177
Neuropsin is essential for early processes of memory acquisition and Schaffer collateral long-term potentiation in adult mouse hippocampus in vivo, J. Physiol, vol.570, pp.541-551, 2006. ,
The fragile X mental retardation protein developmentally regulates the strength and fidelity of calcium signaling in Drosophila mushroom body neurons, Neurobiol. Dis, vol.41, pp.147-159, 2011. ,
Cell-Type-specific translation profiling reveals a novel strategy for treating fragile X Syndrome, Neuron, vol.95, pp.550-563, 2017. ,
Neural ECM proteases in learning and synaptic plasticity, Prog. Brain Res, vol.214, pp.135-157, 2014. ,
AutismKB: an evidence-based knowledgebase of autism genetics, Nucleic Acids Res, vol.40, 2012. ,