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URL : https://hal.archives-ouvertes.fr/hal-02499180
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, In the L. major Friedlin strain, for example, chromosome 2 is 60% monosomic and 40% disomic, chromosome 5 is 30% disomic and 70% trisomic and chromosome 27 is 80% disomic, pp.10-10
In the presented model, two homologs of chromosome 'a' and 'b' are represented in interphase in a diploid hypothesis. In A, chromosome 'b' replicates properly and, during mitosis, segregates in a symmetric manner. Chromosome 'b' was disomic (Di) before cell division and remains disomic afterwards. Chromosome a does not replicate properly due to the non-firing of a replication origin: following the S phase, there are only three copies of chromosome a; an asymmetric segregation occurs, leading to a cell disomic for chromosome 'a' and another one monosomic (Mono) for chromosome 'a'. In B, chromosome 'a' replicates and segregates properly. For chromosome b, replication begins properly but restarts for one of the sister chromatid an over-replication occurs, 2011. ,