Southeastern Sicily is characterized by a prominent topography known as the Hyblean Plateau. It is commonly considered as a flexural bulge formed by the northwest plunging of the Hyblean‐Malta platform beneath the Sicilian Fold and Thrust Belt. However its noncylindrical shape and multiphase uplift history correlated to the Late Miocene and Plio‐Pleistocene volcanism outline a possible magmatic control on the Hyblean Plateau topographic expression. We argue, using 2‐D flexural models, that the flexural bending alone is unlikely to explain the high anomalous elevation of the Hyblean Plateau. Moreover, topographic analysis show that the Hyblean Plateau has a dome shape composed of radially tilted preserved surfaces defining individual blocks. The block edges seem to be related to deep‐seated inherited faults. Using an analogue modeling approach, we show that magmatic intrusions beneath the thick Meso‐Cenozoic sedimentary cover can reproduce the first‐order morphology of the Hyblean Plateau when a structural inheritance is imposed. Accordingly, we propose a tectono‐magmatic model that favors mafic sill intrusions as the major uplift source for the topographic anomaly. However, to explain the strong positive Bouguer anomaly, a deeper high‐density intracrustal body is needed. Moho uprising related to Mesozoic rifting or mafic lower crust underplating/intraplating since the Late Cretaceous can be evoked. The small wavelength of the topography and the deep intracrustal mass anomaly makes the lithospheric elastic stresses sufficiently high to maintain a nonisostatic state over the geological time scales.