F. Abascal, R. Zardoya, and D. Posada, ProtTest: selection of best-fit models of protein evolution, Bioinformatics, vol.21, pp.2104-2109, 2005.

A. Bakar, S. Chee, H. Y. Al-kobaisi, M. F. Xiaoshan, J. Bing et al., Identification of enterovirus 71 isolates from an outbreak of hand, foot and mouth disease (HFMD) with fatal cases of encephalomyelitis in Malaysia, Virus Res, vol.61, pp.1-9, 1999.

L. W. Ang, B. K. Koh, K. P. Chan, L. T. Chua, L. James et al., Epidemiology and control of hand, foot and mouth disease in Singapore, Ann Acad Med Singap, vol.38, pp.106-118, 2009.

B. A. Brown, M. S. Oberste, J. P. Alexander, M. L. Kennett, and M. A. Pallansch, Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998, J Virol, vol.73, pp.9969-75, 1999.

E. A. Caine, L. H. Moncla, M. D. Ronderos, T. C. Friedrich, and J. E. Osorio, A single mutation in the VP1 of Enterovirus 71 is responsible for increased virulence and Neurotropism in adult interferon-deficient mice, J Virol, vol.90, pp.8592-604, 2016.

J. Carter and V. A. Saunders, Virology: principles and applications, 2007.

K. T. Chen, H. L. Chang, S. T. Wang, Y. T. Cheng, and J. Y. Yang, Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, Pediatrics, vol.120, pp.244-52, 1998.

D. Darriba, G. L. Taboada, R. Doallo, and D. Posada, jModelTest 2: more models, new heuristics and parallel computing, Nat Methods, vol.9, issue.8, p.772, 2012.

R. C. Edgar, MUSCLE: a multiple sequence alignment method with reduced time and space complexity, BMC bioinformatics, vol.5, p.113, 2004.

M. Gouy, S. Guindon, and O. Gascuel, SeaView version 4: a multiplatform graphical user interface for sequence alignment and phylogenetic tree building, Mol Biol Evol, vol.27, pp.221-225, 2010.
URL : https://hal.archives-ouvertes.fr/lirmm-00511794

C. C. Huang, C. C. Liu, Y. C. Chang, C. Y. Chen, S. T. Wang et al., Neurologic complications in children with Enterovirus 71 infection, N Engl J Med, vol.341, pp.936-978, 1999.

S. W. Huang, C. H. Tai, J. M. Fonville, C. H. Lin, S. M. Wang et al., Mapping enterovirus A71 antigenic determinants from viral evolution, J Virol, vol.89, pp.11500-11506, 2005.

C. Kataoka, T. Suzuki, O. Kotani, O. Iwata-yoshikawa, N. Nagata et al., The role of VP1 amino acid residue 145 of Enterovirus 71 in viral fitness and pathogenesis in a Cynomolgus monkey model, PLoS Pathog, vol.11, issue.7, p.1005033, 2015.

T. H. Khanh, S. Sabanathan, T. T. Thanh, P. K. Thoa-le, T. C. Thuong et al., Enterovirus 71-associated hand, foot, and mouth disease, southern Vietnam, Emerging Infect Dis, vol.18, pp.2002-2007, 2011.

S. K. Lal, P. Kumar, W. M. Yeo, A. Kar-roy, and V. T. Chow, The VP1 protein of human enterovirus 71 self-associates via an interaction domain spanning amino acids 66-297, J Med Virol, vol.78, pp.582-90, 2006.

R. Li, Q. Zou, L. Chen, H. Zhang, and Y. Wang, Molecular analysis of virulent determinants of enterovirus 71, PLoS One, vol.6, issue.10, p.26237, 2011.

P. Librado and J. Rozas, DnaSP v5: a software for comprehensive analysis of DNA polymorphism data, Bioinformatics, vol.25, pp.1451-1453, 2009.

P. Mcminn, K. Lindsay, D. Perera, H. M. Chan, K. P. Chan et al., Phylogenetic analysis of enterovirus 71 strains isolated during linked epidemics in Malaysia, J Virol, vol.75, pp.7732-7740, 2001.

N. Nguyen, H. Pham, C. Q. Hoang, T. M. Nguyen, L. T. Nguyen et al., Epidemiological and clinical characteristics of children who died from hand, foot and mouth disease in Vietnam, BMC Infect Dis, vol.14, p.341, 2011.

W. A. Nix, M. S. Oberste, and M. A. Pallansch, Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens, J Clin Microbiol, vol.44, pp.2698-704, 2006.

M. H. Ooi, S. C. Wong, P. Lewthwaite, M. J. Cardosa, and T. Solomon, Clinical features, diagnosis, and management of enterovirus 71, The Lancet Neurology, vol.9, pp.1097-105, 2010.

D. Perera, Y. Podin, W. Akin, C. S. Tan, and M. J. Cardosa, Incorrect identification of recent Asian strains of Coxsackievirus A16 as human enterovirus 71: improved primers for the specific detection of human enterovirus 71 by RT PCR, BMC Infect Dis, vol.4, p.11, 2004.

F. W. Peyerl, D. H. Barouch, W. W. Yeh, H. S. Bazick, J. Kunstman et al., Simian-human immunodeficiency virus escape from cytotoxic Tlymphocyte recognition at a structurally constrained epitope, J Virol, vol.77, pp.12572-12580, 2003.

S. Sanders, L. Herrero, K. Mcphie, S. Chow, M. Craig et al., Molecular epidemiology of enterovirus 71 over two decades in an Australian urban community, Arch Virol, vol.151, pp.1003-1016, 2006.

M. Schmidtke, E. Hammerschmidt, S. Schüler, R. Zell, E. Birch-hirschfeld et al., Susceptibility of coxsackievirus B3 laboratory strains and clinical isolates to the capsid function inhibitor pleconaril: antiviral studies with virus chimeras demonstrate the crucial role of amino acid 1092 in treatment, J Antimicrob Chemother, vol.56, pp.648-56, 2005.

P. F. Szurek, P. H. Yuen, J. K. Ball, and P. K. Wong, A Val-25-to-Ile substitution in the envelope precursor polyprotein, gPr80env, is responsible for the temperature sensitivity, inefficient processing of gPr80env, and neurovirulence of ts1, a mutant of Moloney murine leukemia virus TB, J Virol, vol.64, pp.467-75, 1990.

K. K. Tee, T. Lam, Y. F. Chan, J. M. Bible, A. Kamarulzaman et al., Evolutionary genetics of human enterovirus 71: origin, population dynamics, natural selection, and seasonal periodicity of the VP1 gene, J Virol, vol.84, pp.3339-50, 2010.

P. V. Tu, N. Thao, D. Perera, T. K. Huu, N. Tien et al., Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, Emerging Infect Dis, vol.13, pp.1733-1774, 2005.

, A Guide to Clinical Management and Public Health Response for Hand, Foot and Mouth Disease (HFMD), 2011.

Y. Yamaguchi, Y. Nukui, S. Tajima, R. Nerome, F. Kato et al., An amino acid substitution (V3I) in the Japanese encephalitis virus NS4A protein increases its virulence in mice, but not its growth rate in vitro, J Gen Virol, vol.92, pp.1601-1607, 2011.

S. L. Yang, Y. T. Chou, C. N. Wu, and M. S. Ho, Annexin II binds to capsid protein VP1 of enterovirus 71 and enhances viral infectivity, J Virol, vol.85, pp.11809-11829, 2011.

F. Yu, X. Ren, Y. Wang, X. Qi, J. Song et al., A single amino acid V4I substitution in VP1 attenuates virulence of very virulent infectious bursal disease virus (vvIBDV) in SPF chickens and increases replication in CEF cells, Virology, vol.440, pp.204-213, 2013.

M. Zeng, Y. F. Li, X. H. Wang, G. P. Lu, H. G. Shen et al., Epidemiology of hand, foot, and mouth disease in children in shanghai, Epidemiol Infect, vol.140, pp.1122-1152, 2007.