Sumo-1 Function Is Dispensable in Normal Mouse Development, Mol. Cell. Biol, vol.28, pp.5381-5390, 2008. ,
Small Ubiquitin-Like Modifier 4 (SUMO4) Gene M55V Polymorphism and Type 2 Diabetes Mellitus: A Meta-Analysis Including 6,823 Subjects ,
, SUMO5, a Novel Poly-SUMO Isoform, 2016.
SUMO conjugation-A mechanistic view, vol.8, pp.13-36, 2017. ,
The RanBP2/RanGAP1*SUMO1/Ubc9 complex is a multisubunit SUMO E3 ligase, Mol. Cell, vol.46, pp.287-298, 2012. ,
Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase, Nat. Struct. Mol. Biol, vol.22, pp.968-975, 2015. ,
A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly, Nat. Struct. Mol. Biol, vol.22, pp.959-967, 2015. ,
SUMO-specific proteases and isopeptidases of the SENP family at a glance, J. Cell Sci, vol.131, 2018. ,
A role for the CB-associated SUMO isopeptidase USPL1 in RNAPII-mediated snRNA transcription, J. Cell Sci, 2014. ,
Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions, EMBO Rep, vol.13, pp.930-938, 2012. ,
Crystal structure of DeSI-1, a novel deSUMOylase belonging to a putative isopeptidase superfamily, Proteins, vol.80, pp.2099-2104, 2012. ,
Dikic, I. Specification of SUMO1-and SUMO2-interacting Motifs, J. Biol. Chem, vol.281, pp.16117-16127, 2006. ,
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation, Nat. Struct. Mol. Biol, vol.24, pp.325-336, 2017. ,
A comprehensive compilation of SUMO proteomics, Nat. Rev. Mol. Cell Biol, vol.17, pp.581-595, 2016. ,
SUMO-mediated regulation of nuclear functions and signaling processes, Mol. Cell, vol.71, pp.409-418, 2018. ,
The SUMO Pathway Is Essential for Nuclear Integrity and Chromosome Segregation in Mice, Dev. Cell, vol.9, pp.769-779, 2005. ,
URL : https://hal.archives-ouvertes.fr/pasteur-02075525
Wrestling with SUMO in a New Arena, Sci. Signal, p.32, 2005. ,
SUMO, a small, but powerful, regulator of double-strand break repair, Philos. Trans. R. Soc. Lond. B Biol. Sci, vol.372, 2017. ,
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks, Nature, vol.462, pp.935-939, 2009. ,
Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair, Cell, vol.151, pp.807-820, 2012. ,
SUMO-Targeted Ubiquitin E3 Ligase RNF4 Is Required for the Response of Human Cells to DNA Damage, Genes Dev, vol.26, pp.1196-1208, 2012. ,
The SUMO system: A master organizer of nuclear protein assemblies, Chromosoma, vol.122, pp.475-485, 2013. ,
Regulation of transcription factors by sumoylation, vol.8, pp.220-231, 2017. ,
SUMO-regulated transcription: Challenging the dogma, BioEssays News Rev. Mol. Cell. Dev. Biol, vol.37, pp.1095-1105, 2015. ,
Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation, Genome Res, vol.23, pp.1563-1579, 2013. ,
SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States, Cell Stem Cell, vol.23, pp.742-757, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02187057
Identification of Regulators of the Three-Dimensional Polycomb Organization by a Microscopy-Based Genome-wide RNAi Screen, Mol. Cell, vol.54, pp.485-499, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01002712
SUMO under stress, Biochem. Soc. Trans, vol.36, pp.874-878, 2008. ,
Sumo and the cellular stress response, Cell Div, vol.10, issue.4, 2015. ,
Regulation of SUMOylation by Reversible Oxidation of SUMO Conjugating Enzymes, Mol. Cell, vol.21, pp.349-357, 2006. ,
Redox regulation of SUMO enzymes is required for ATM activity and survival in oxidative stress, EMBO J, vol.35, pp.1312-1329, 2016. ,
Control of SUMO and Ubiquitin by ROS: Signaling and disease implications, Mol. Aspects Med, vol.63, pp.3-17, 2018. ,
Proteotoxic stress reprograms the chromatin landscape of SUMO modification, Sci Signal, vol.8, p.7, 2015. ,
SUMO and the robustness of cancer, Nat. Rev. Cancer, vol.17, pp.184-197, 2017. ,
A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene, Cell, vol.137, pp.835-848, 2009. ,
Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9, Proc. Natl. Acad. Sci, vol.112, pp.1724-1733, 2015. ,
A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis, Science, vol.335, pp.348-353, 2011. ,
NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation, Oncogene, vol.34, pp.3780-3790, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-02287227
A translocation t(2;8)(q12;p11) fuses FGFR1 to a novel partner gene, RANBP2/NUP358, in a myeloproliferative/myelodysplastic neoplasm, Leukemia, vol.27, pp.1186-1188, 2013. ,
Identification of RANBP2-ALK fusion in ALK positive diffuse large B-cell lymphoma, Hematol. Oncol, vol.32, pp.221-224, 2014. ,
RANBP2-ALK fusion combined with monosomy 7 in acute myelomonocytic leukemia, Cancer Genet, vol.207, pp.40-45, 2014. ,
Reduction of leukemia cell burden and restoration of normal hematopoiesis at 3 months of crizotinib treatment in RAN-binding protein 2 (RANBP2)-anaplastic lymphoma kinase (ALK) acute myeloid leukemia, Leukemia, vol.28, pp.1935-1937, 2014. ,
Crizotinib resistance in acute myeloid leukemia with inv(2)(p23q13)/RAN binding protein 2 (RANBP2) anaplastic lymphoma kinase (ALK) fusion and monosomy 7, Cancer Genet, vol.208, pp.85-90, 2015. ,
The post-translational modification, SUMOylation, and cancer (Review), Int. J. Oncol, vol.52, pp.1081-1094, 2018. ,
SUMO pathway components as possible cancer biomarkers, Future Oncol, vol.11, pp.1599-1610, 2015. ,
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma, Nature, vol.480, pp.94-98, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-01791271
Deciphering the Role of Oncogenic MITFE318K in Senescence Delay and Melanoma Progression, J. Natl. Cancer Inst, vol.109, 2017. ,
URL : https://hal.archives-ouvertes.fr/inserm-02529960
RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway, J. Clin. Investig, vol.125, pp.1523-1532, 2015. ,
Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management, Am. J. Hematol, vol.87, pp.89-99, 2012. ,
An update of current treatments for adult acute myeloid leukemia, Blood, vol.127, pp.53-61, 2016. ,
Recent advances in acute promyelocytic leukaemia, vol.6, 1000. ,
The PML-RAR? fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR, Cell, vol.66, pp.675-684, 1991. ,
Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells, Cell, vol.76, pp.345-356, 1994. ,
The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion, EMBO J, vol.13, pp.1073-1083, 1994. ,
PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia, Oncogene, vol.13, pp.971-982, 1996. ,
Oxidative stress-induced assembly of PML nuclear bodies controls sumoylation of partner proteins, J. Cell Biol, vol.204, pp.931-945, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-02348929
PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3, Cancer Cell, vol.18, pp.88-98, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00652202
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation, Nat. Cell Biol, vol.10, pp.538-546, 2008. ,
Arsenic degrades PML or PML-RAR? through a SUMO-triggered RNF4/ubiquitin-mediated pathway, Nat. Cell Biol, vol.10, pp.547-555, 2008. ,
Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure, Nat. Med, vol.20, pp.167-174, 2014. ,
The multifaceted functions of C/EBP? in normal and malignant haematopoiesis, Leukemia, vol.30, pp.767-775, 2015. ,
Target proteins of C/EBP?p30 in AML: C/EBP?p30 enhances sumoylation of C/EBP?p42 via up-regulation of Ubc9, Blood, vol.110, pp.3301-3309, 2007. ,
Differential effects of sumoylation on the activities of CCAAT enhancer binding protein alpha (C/EBP?) p42 versus p30 may contribute in part, to aberrant C/EBP? activity in acute leukemias, Hematol ,
SUMOylation of insulin-like growth factor 1 receptor, promotes proliferation in acute myeloid leukemia, Cancer Lett, vol.357, pp.297-306, 2015. ,
Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice, J. Clin. Investig, vol.117, pp.3696-3707, 2007. ,
SUMOylation of sPRDM16 promotes the progression of acute myeloid leukemia, BMC Cancer, vol.15, 2015. ,
Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation, Oncogene, vol.30, pp.4194-4207, 2011. ,
Kitabayashi, I. Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1-and p53-mediated transcription, Oncogene, vol.26, pp.7231-7239, 2007. ,
Functional impairment of the HIPK2 small ubiquitin-like modifier (SUMO)-interacting motif in acute myeloid leukemia, Am. J. Cancer Res, vol.9, pp.94-107, 2019. ,
Role and potential for therapeutic targeting of MYB in leukemia, Leukemia, vol.27, pp.269-277, 2013. ,
A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability, Oncogene, vol.30, pp.212-222, 2011. ,
The ROS/SUMO Axis Contributes to the Response of Acute Myeloid Leukemia Cells to Chemotherapeutic Drugs, Cell Rep, vol.7, pp.1815-1823, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-02191559
An Electrophoretic Mobility Shift Assay Identifies a Mechanistically Unique Inhibitor of Protein Sumoylation, Chem. Biol, vol.20, pp.604-613, 2013. ,
2-D08 as a SUMOylation inhibitor induced ROS accumulation mediates apoptosis of acute myeloid leukemia cells possibly through the deSUMOylation of NOX2, Biochem. Biophys. Res. Commun, vol.513, pp.1063-1069, 2019. ,
The HDAC inhibitor SAHA regulates CBX2 stability via a SUMO-triggered ubiquitin-mediated pathway in leukemia, Oncogene, vol.37, pp.2559-2572, 2018. ,
An ATRActive future for differentiation therapy in AML, Blood Rev, vol.29, pp.263-268, 2015. ,
Small ubiquitin-related modifier-1 modification regulates all-trans-retinoic acid-induced differentiation via stabilization of retinoic acid receptor ?, FEBS J, vol.281, pp.3032-3047, 2014. ,
Targeting the SUMO Pathway Primes All-trans Retinoic Acid-Induced Differentiation of Nonpromyelocytic Acute Myeloid Leukemias, Cancer Res, vol.78, pp.2601-2613, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02348613
Defining and treating high-risk multiple myeloma, Leukemia, vol.29, pp.2119-2125, 2015. ,
, Lancet, vol.385, pp.2197-2208, 2015.
Novel therapeutic strategies for multiple myeloma, Exp. Hematol, vol.43, pp.732-741, 2015. ,
Multiple myeloma: Every year a new standard?, Hematol. Oncol, vol.37, pp.62-65, 2019. ,
The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome, Blood, vol.115, pp.2827-2834, 2010. ,
SENP1 inhibition induces apoptosis and growth arrest of multiple myeloma cells through modulation of NF-?B signaling, Biochem. Biophys. Res. Commun, vol.460, pp.409-415, 2015. ,
?-catenin SUMOylation is involved in the dysregulated proliferation of myeloma cells, Am. J. Cancer Res, vol.5, pp.309-320, 2014. ,
The 2016 revision of the World Health Organization classification of lymphoid neoplasms, Blood, vol.127, pp.2375-2390, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01800015
Pathogenesis and therapeutic targeting of aberrant MYC expression in haematological cancers, Br. J. Haematol, vol.179, pp.724-738, 2017. ,
Myc Roles in Hematopoiesis and Leukemia, Genes Cancer, vol.1, pp.605-616, 2010. ,
Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma, Blood, vol.124, pp.2081-2090, 2014. ,
SUMOylation of Myc-Family Proteins, PLoS ONE, vol.9, 2014. ,
A.; Vertegaal, A.C. c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4, Cell Cycle, vol.14, pp.1859-1872, 2015. ,
, Promotes Lymphomagenesis through MYC Upregulation. Cell Rep, vol.15, pp.2266-2278, 2016.
40 years of the human T-cell leukemia virus: Past, present, and future, 2019. ,
A Fascinating Multifunctional Co-Regulator of Viral and Cellular Pathways, Front. Microbiol, vol.3, p.406, 2012. ,
The Complementary Strand of the Human T-Cell Leukemia Virus Type 1 RNA Genome Encodes a bZIP Transcription Factor That Down-Regulates Viral Transcription, J. Virol, vol.76, pp.12813-12822, 2002. ,
URL : https://hal.archives-ouvertes.fr/hal-00188771
HBZ-mediated shift of JunD from growth suppressor to tumor promoter in leukemic cells by inhibition of ribosomal protein S25 expression, vol.31, pp.2235-2243, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-02120104
HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells, Proc. Natl. Acad. Sci, vol.103, pp.720-725, 2006. ,
ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation, Blood, vol.125, pp.474-482, 2015. ,
Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia, J. Exp. Med, vol.207, pp.2785-2792, 2010. ,
Arsenic-interferon-?-triggered apoptosis in HTLV-I transformed cells is associated with Tax down-regulation and reversal of NF-?B activation, Blood, vol.96, pp.2849-2855, 2000. ,
Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL), Blood, vol.113, pp.6528-6532, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-00408123
The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax, Blood, vol.119, pp.1173-1181, 2012. ,
Small molecular inhibitors targeting protein SUMOylation as novel anticancer compounds, Mol. Pharmacol, vol.94, pp.885-894, 2018. ,
Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor, Nat. Chem. Biol, vol.13, pp.1164-1171, 2017. ,
Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme, Nat. Commun, vol.9, 2018. ,
Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme, Cell Chem. Biol, vol.26, pp.278-288, 2019. ,
Phase I Study of Fenretinide Delivered Intravenously in Patients with Relapsed or Refractory Hematologic Malignancies: A California Cancer Consortium Trial, Clin. Cancer Res, vol.23, pp.4550-4555, 2017. ,
Dynamics of ceramide generation and metabolism in response to fenretinide-diversity within and among leukemia, Leuk. Res, vol.39, pp.1071-1078, 2015. ,
Epigenetic therapy in hematological cancers, APMIS, vol.127, pp.316-328, 2019. ,
Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate, Chem. Biol, vol.16, pp.133-140, 2009. ,
Kerriamycin B inhibits protein SUMOylation, J. Antibiot, vol.62, pp.221-224, 2009. ,
Spectomycin B1 as a Novel SUMOylation Inhibitor That Directly Binds to SUMO E2, ACS Chem. Biol, vol.8, pp.2635-2642, 2013. ,
Synthesis of 2 ,3 ,4 -trihydroxyflavone (2-D08), an inhibitor of protein sumoylation, Bioorg. Med. Chem. Lett, vol.24, pp.1094-1097, 2014. ,
Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata, J. Antibiot, vol.67, pp.335-338, 2014. ,
A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver ,