Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

Monique Breteler Matthias Mauschitz Pieter W.M. Bonnemaijer Kersten Diers Franziska Rauscher Tobias Elze Christoph Engel Markus Loeffler Johanna Maria Colijn M. Arfan Ikram Johannes Vingerling Katie Williams Christopher Hammond Catherine Creuzot-Garcher 1, 2 Alain Bron 1, 2 Rufino Silva Sandrina Nunes Cécile Delcourt 3 Audrey Cougnard-Grégoire 3 Frank Holz Caroline C.W. Klaver Monique M.B. Breteler Robert Finger Niyazi Acar Eleftherios Anastosopoulos Augusto Azuara-Blanco Tos Berendschot Arthur Bergen Geir Bertelsen Christine Binquet Alan Bird Martin Bobak Morten Bøgelund Larsen Camiel Boon Rupert Bourne Lionel Bretillon Rebecca Broe Gabrielle Buitendijk Maria Luz Cachulo Vittorio Capuano Isabelle Carrière Usha Chakravarthy Michelle Chan Petrus Chang Johanna Colijn Angela Cree Phillippa Cumberland José Cunha-Vaz Vincent Daien 4, 5 Eiko de Jong Gabor Deak Marie-Noëlle Delyfer Anneke Den Hollander Martha Dietzel Maja Gran Erke Pedro Faria Claudia Farinha Sascha Fauser Astrid Fletcher Paul Foster Panayiota Founti Theo Gorgels Jakob Grauslund Franz Grus Hans-Werner Hense Manuel Hermann René Hoehn Ruth Hogg Carel Hoyng Nomdo Jansonius Sarah Janssen Eveline Kersten Anthony Khawaja Caroline Klaver Jean-François Korobelnik Julia Lamparter Mélanie Le Goff Yara Lechanteur Terho Lehtimäki Irene Leung Andrew Lotery Magda Meester Bénédicte Merle Verena Meyer zu Westrup Edoardo Midena Stefania Miotto Alireza Mirshahi Sadek Mohan-Saïd Michael Mueller Alyson Muldrew Joaquim Murta Stefan Nickels Christopher Owen Tunde Peto Norbert Pfeiffer Stefano Piermarocchi Elena Prokofyeva Jugnoo Rahi Olli Raitakari Luisa Ribeiro Marie-Bénédicte Rougier Alicja Rudnicka José Sahel Aggeliki Salonikiou Clarisa Sanchez Steffen Schmitz-Valckenberg Alexander Schuster Cédric Schweitzer Tatiana Segato Jasmin Shehata Giuliana Silvestri Christian Simader Eric Souied Martynas Speckauskas Henriët Springelkamp Robyn Tapp Fotis Topouzis Elisa van Leeuwen Virginie Verhoeven Timo Verzijden Therese von Hanno Peter Wiedemann Christian Wolfram Jennifer Yip Jennyfer Zerbib
Abstract : PURPOSE: To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population. DESIGN: Cross-sectional meta-analysis. PARTICIPANTS: A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3-82.1±4.2 years) of the European Eye Epidemiology (E3) consortium. METHODS: We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis. MAIN OUTCOME MEASURES: Determinants of pRNFLT. RESULTS: Mean pRNFLT ranged from 86.8±21.4 μm in the Rotterdam Study I to 104.7±12.5 μm in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (β = -0.38 μm/year; 95% confidence interval [CI], -0.57 to -0.18), higher intraocular pressure (IOP) (β = -0.36 μm/mmHg; 95% CI, -0.56 to -0.15), visual impairment (β = -5.50 μm; 95% CI, -9.37 to -1.64), and history of systemic hypertension (β = -0.54 μm; 95% CI, -1.01 to -0.07) and stroke (β = -1.94 μm; 95% CI, -3.17 to -0.72). A suggestive, albeit nonsignificant, association was observed for dementia (β = -3.11 μm; 95% CI, -6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (β = 1.39 μm/diopter; 95% CI, 1.19-1.59) and smoking (β = 1.53 μm; 95% CI, 1.00-2.06 for current smokers compared with never-smokers). CONCLUSIONS: In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities.
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Soumis le : jeudi 31 octobre 2019 - 13:52:44
Dernière modification le : jeudi 20 février 2020 - 19:23:41

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Monique Breteler, Matthias Mauschitz, Pieter W.M. Bonnemaijer, Kersten Diers, Franziska Rauscher, et al.. Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population. Ophthalmology: Journal of The American Academy of Ophthalmology, Elsevier, 2018, 125 (10), pp.1526-1536. ⟨10.1016/j.ophtha.2018.03.026⟩. ⟨hal-02341481⟩

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