The enigma of multicentric glioblastoma: physiopathogenic hypothesis and discussion about two cases

Abstract : Two men were admitted following generalized seizures. Cerebral MRI-scans showed multiple independent enhancing lesions which were bilateral (first case) and unilateral but disseminated to the brainstem (second case). Whole-body CT-scans showed no primaries. Both cases were diagnosed by biopsy as IDH1 wild-type multicentric glioblastoma. Treatment of both was palliative. The natural history of this entity remains matter of debate but 2 genomic analysis strikingly revealed that foci from the same patient were of monoclonal origin. Consistently, these 2 cases could sustain the hypothesis that an anatomical connectivity exists between the different foci of a multicentric glioblastoma.
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https://hal.umontpellier.fr/hal-02315538
Contributeur : Anthony Herrada <>
Soumis le : lundi 14 octobre 2019 - 15:18:44
Dernière modification le : mardi 15 octobre 2019 - 01:19:10

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Thiébaud Picart, Marine Le Corre, Emilie Chan-Seng, Jérôme Cochereau, Hugues Duffau. The enigma of multicentric glioblastoma: physiopathogenic hypothesis and discussion about two cases. British Journal of Neurosurgery, Taylor & Francis, 2018, 32 (6), pp.610-613. ⟨10.1080/02688697.2018.1501465⟩. ⟨hal-02315538⟩

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