SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes, J Cell Biol, vol.166, pp.37-47, 2004. ,
URL : https://hal.archives-ouvertes.fr/hal-00266987
Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium, J Cell Biol, vol.178, pp.635-648, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00267010
SOX9 is required for the differentiation of paneth cells in the intestinal epithelium, Gastroenterology, vol.133, pp.539-546, 2007. ,
Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium, Am J Physiol Gastrointest Liver Physiol, vol.296, pp.1108-1118, 2009. ,
Expression of the carcinoembryonic antigen gene is inhibited by SOX9 in human colon carcinoma cells, Cancer Res, vol.65, pp.2193-2198, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-00017040
Analysis of SOX9 expression in colorectal cancer, Am J Clin Pathol, vol.130, pp.897-904, 2008. ,
Defective claudin-7 regulation by Tcf-4 and Sox-9 disrupts the polarity and increases the tumorigenicity of colorectal cancer cells, Cancer Res, vol.68, pp.4258-4268, 2008. ,
, Comprehensive molecular characterization of human colon and rectal cancer, Nature, vol.487, pp.330-337, 2012.
MiniSOX9, a dominant-negative variant in colon cancer cells, Oncogene, vol.30, pp.2493-2503, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00615517
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene, Science, vol.278, pp.120-123, 1997. ,
Intestinal tumor progression is promoted by decreased apoptosis and dysregulated Wnt signaling in Ceacam1?/? mice, Oncogene, vol.27, pp.4943-4953, 2008. ,
CEACAM1, a SOX9 direct transcriptional target identified in the colon epithelium, Oncogene, vol.27, pp.7131-7138, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00357151
Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleus, J Biol Chem, vol.284, pp.3323-3333, 2009. ,
KLF4 and SOX9 transcription factors antagonize beta-catenin and inhibit TCF-activity in cancer cells, Biochimica et biophysica acta, vol.1823, pp.1666-1675, 2012. ,
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer, Cancer research, vol.74, pp.3238-3247, 2014. ,
Cancer stem cells. The New England journal of medicine, vol.355, pp.1253-1261, 2006. ,
,
, Tsitologiia, vol.49, pp.916-922, 2007.
Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma, BMC Genomics, vol.15, p.190, 2014. ,
Gastrointestinal stem cells in development and cancer, The Journal of pathology, vol.217, pp.307-317, 2009. ,
The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres, Molecular cancer, vol.9, p.212, 2010. ,
Identification of c-MYC as a target of the APC pathway, Science, vol.281, pp.1509-1512, 1998. ,
Myc deletion rescues Apc deficiency in the small intestine, Nature, vol.446, pp.676-679, 2007. ,
Expression and biological role of the prostaglandin D synthase/SOX9 pathway in human ovarian cancer cells, Cancer Lett, vol.255, pp.182-193, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00168631
Suppression of growth and tumorigenicity in the prostate tumor cell line M12 by overexpression of the transcription factor SOX9, Oncogene, vol.23, pp.4584-4593, 2004. ,
SOX9 is expressed in normal prostate basal cells and regulates androgen receptor expression in prostate cancer cells, Cancer Res, vol.67, pp.528-536, 2007. ,
SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion, Cancer Res, vol.68, pp.1625-1630, 2008. ,
Identification of DNA hypermethylation of SOX9 in association with bladder cancer progression using CpG microarrays, Br J Cancer, vol.98, pp.466-473, 2008. ,
SOX9 directly regulates IGFBP-4 in the intestinal epithelium, Am J Physiol Gastrointest Liver Physiol, vol.305, pp.74-83, 2013. ,
Prognostic Significance of betaCatenin, E-Cadherin, and SOX9 in Colorectal Cancer: Results from a Large Population-Representative Series, Front Oncol, vol.4, p.118, 2014. ,
SOX9 Expression Predicts Relapse of Stage II Colon Cancer Patients, Human pathology, vol.52, pp.38-46, 2016. ,
A colon tumor model for anticancer agent evaluation, Cancer, vol.36, pp.2441-2444, 1975. ,
Oncogenicity of the developmental transcription factor Sox9, Cancer research, vol.72, pp.1301-1315, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00768487
The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors, Nucleic Acids Res, vol.34, pp.1735-1744, 2006. ,
A new mechanism of SOX9 action to regulate PKCalpha expression in the intestine epithelium, J Cell Sci, vol.122, pp.2191-2196, 2009. ,
Contextspecific role of SOX9 in NF-Y mediated gene regulation in colorectal cancer cells, Nucleic acids research, vol.43, pp.6257-6269, 2015. ,
Evaluation of reference genes and normalization strategy for quantitative real-time PCR in human pancreatic carcinoma, Disease markers, vol.32, pp.203-210, 2012. ,