Kinetics of circulating cell-free DNA for biomedical applications: critical appraisal of the literature

Abstract : Circulating cell-free DNA is considered as one of the major breakthroughs in the field of innovative diagnosis, used as a liquid biopsy. The kinetic parameters of a biomarker are mandatory to assess its usefulness as a diagnostic tool. Obtaining precise mathematical values for the kinetic parameters (e.g., half-life) is then crucial because it could be used for therapeutic monitoring as a prognostic factor. However, little is known about the intrinsic properties of circulating cell-free DNA, more especially, its kinetic properties within the organism. We summarized the basic principles that may affect the kinetics of circulating cell-free DNA within the organism in the light of biological and clinical evidence. We also meta-analyzed the reported data in the literature and the methodologies that have been used to study the kinetic parameters of human circulating cell-free DNA in vivo.
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https://hal.umontpellier.fr/hal-02289772
Contributeur : Anthony Herrada <>
Soumis le : mardi 17 septembre 2019 - 10:20:59
Dernière modification le : lundi 7 octobre 2019 - 08:54:02

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Sonia Khier, Laura Lohan. Kinetics of circulating cell-free DNA for biomedical applications: critical appraisal of the literature. Future Science OA, 2018, 4 (4), pp.FSO295. ⟨10.4155/fsoa-2017-0140⟩. ⟨hal-02289772⟩

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