Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012, Int J Cancer, vol.136, pp.359-86, 2015. ,
Recent advances in non-small cell lung cancer biology and clinical management, Discov Med, vol.13, pp.287-97, 2012. ,
Epithelial-mesenchymal transitions in tumour progression, Nat Rev Cancer, vol.2, pp.442-54, 2002. ,
Epithelial mesenchymal transition in aggressive lung cancers, Adv Exp Med Biol, vol.890, pp.37-56, 2016. ,
Neutrophils and snail orchestrate the establishment of a Pro-tumor microenvironment in lung cancer, Cell Reports, vol.21, pp.3190-204, 2017. ,
Prognostic significance of hypoxia-inducible factor-1?, TWIST1 and Snail expression in resectable non-small cell lung cancer, Thorax, vol.64, pp.1082-89, 2009. ,
Snail promotes CXCR2 ligand-dependent tumor progression in non-small cell lung carcinoma, Clin Cancer Res, vol.15, pp.6820-6849, 2009. ,
The differential effects of mutant p53 alleles on advanced murine lung cancer, Cancer Res, vol.65, pp.10280-88, 2005. ,
Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages, Cancer Cell, vol.26, pp.534-582, 2014. ,
Snail cooperates with Kras G12D in vivo to increase stem cell factor and enhance mast cell infiltration, Mol Cancer Res, vol.12, pp.1440-1488, 2014. ,
Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells, Cancer Cell, vol.15, pp.195-206, 2009. ,
The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis, Cell Mol Life Sci, vol.70, pp.795-814, 2013. ,
Deletion of Gtl2, imprinted non-coding RNA, with its differentially methylated region induces lethal parent-origin-dependent defects in mice, Hum Mol Genet, vol.18, pp.1879-88, 2009. ,
Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene, Development, vol.137, pp.2643-52, 2010. ,
DLK1-DIO3 imprinted locus deregulation in development, respiratory disease, and cancer, Expert Rev Respir Med, vol.11, pp.749-61, 2017. ,
Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention, J Exp Clin Cancer Res, vol.33, p.62, 2014. ,
,
The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells, Biochem J, vol.394, pp.449-57, 2006. ,
Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail, J Cell Sci, vol.116, pp.1959-67, 2003. ,
Snail promotes an invasive phenotype in lung carcinoma, Respir Res, vol.13, 2012. ,
Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma, Oncogene, vol.34, pp.94-103, 2015. ,
The biology and function of exosomes in cancer, J Clin Invest, vol.126, pp.1208-1223, 2016. ,
Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes, Proc Natl Acad Sci U S A, vol.113, pp.968-77, 2016. ,
DLK1 Protein Expression during Mouse Development Provides New Insights into Its Function, ISRN Developmental Biology, vol.2013, 2013. ,
Maternally imprinted microRNAs are differentially expressed during mouse and human lung development, Dev Dyn, vol.236, pp.572-80, 2007. ,
A MicroRNA cluster at 14q32 drives aggressive lung adenocarcinoma, Clin Cancer Res, vol.20, pp.3107-3124, 2014. ,
Deregulation of small noncoding RNAs at the DLK1-DIO3 imprinted locus predicts lung cancer patient outcome, Oncotarget, vol.7, pp.80957-66, 2016. ,
Impact of DLK1-DIO3 imprinted cluster hypomethylation in smoker patients with lung cancer, Oncotarget, vol.9, pp.4395-410, 2016. ,
The prognostic value of long non coding RNAs in non small cell lung cancer: A meta-analysis, Oncotarget, vol.7, pp.81292-304, 2016. ,
MEG3 noncoding RNA: a tumor suppressor, J Mol Endocrinol, vol.48, pp.45-53, 2012. ,
miR-134 inhibits non-small cell lung cancer growth by targeting the epidermal growth factor receptor, J Cell Mol Med, vol.20, pp.1974-83, 2016. ,
Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity, Genes Dev, vol.30, pp.92-101, 2016. ,
PRC2 is required to maintain expression of the maternal gtl2-rian-mirg locus by preventing de novo dna methylation in mouse embryonic stem cells, Cell Reports, vol.12, pp.1456-70, 2015. ,
Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells, J Biol Chem, vol.285, pp.19483-90, 2010. ,
At least ten genes define the imprinted Dlk1-Dio3 cluster on mouse chromosome 12qF1, PLoS One, vol.4, 2009. ,
Loss of imprinting and cancer, J Pathol, vol.211, pp.261-68, 2007. ,
Genome-wide analysis reveals downregulation of miR-379/miR-656 cluster in human cancers, Biol Direct, vol.8, issue.10, 2013. ,
MicroRNAs in the imprinted DLK1-DIO3 region repress the epithelial-tomesenchymal transition by targeting the TWIST1 protein signaling network, J Biol Chem, vol.287, pp.42695-707, 2012. ,
DLK1 promotes lung cancer cell invasion through upregulation of MMP9 expression depending on Notch signaling, PLoS One, vol.9, 2014. ,
Targeted disruption of Hotair leads to homeotic www.oncotarget.com transformation and gene derepression, Cell Reports, vol.5, pp.3-12, 2013. ,
The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-tomesenchymal transition, Oncogene, vol.36, pp.942-55, 2017. ,
miR-377-dependent BCL-xL regulation drives chemotherapeutic resistance in B-cell lymphoid malignancies, Mol Cancer, vol.14, p.185, 2015. ,
Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells, Mol Psychiatry, vol.17, pp.827-867, 2012. ,
Identification of a common lupus diseaseassociated microRNA expression pattern in three different murine models of lupus, PLoS One, vol.5, 2010. ,
The Upregulation of genomic imprinted DLK1-Dio3 miRNAs in murine lupus is associated with global DNA Hypomethylation, PLoS One, vol.11, 2016. ,
Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase, Nat Protoc, vol.4, pp.1064-72, 2009. ,
Analyzing real-time PCR data by the comparative C(T) method, Nat Protoc, vol.3, pp.1101-1109, 2008. ,
limma powers differential expression analyses for RNA-sequencing and microarray studies, Nucleic Acids Res, vol.43, pp.47-47, 2015. ,
Gene set enrichment analysis: a knowledge-based approach for interpreting genomewide expression profiles, Proc Natl Acad Sci U S A, vol.102, pp.15545-50, 2005. ,