S. Darby, P. Mcgale, C. Correa, C. Taylor, R. Arriagada et al., Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials, Lancet, vol.378, issue.11, pp.61629-61631, 2011.

M. Dowsett, J. F. Forbes, R. Bradley, J. Ingle, T. Aihara et al., Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials, Lancet, vol.386, pp.61074-61075, 2015.

S. K. Al-ghazal, L. Fallowfield, and R. W. Blamey, Does cosmetic outcome from treatment of primary breast cancer influence psychosocial morbidity?, Eur J Surg Oncol, vol.25, pp.571-574, 1999.

S. C. Darby, M. Ewertz, and P. Hall, Ischemic heart disease after breast cancer radiotherapy, N Engl J Med, vol.368, p.2527, 2013.

D. Azria, M. Betz, C. Bourgier, J. Sozzi, W. Ozsahin et al., Identifying patients at risk for late radiation-induced toxicity, Crit Rev Oncol Hematol, vol.84, pp.35-41, 2012.

C. Bourgier, J. Lacombe, J. Solassol, A. Mange, A. Pelegrin et al., Late side-effects after curative intent radiotherapy: Identification of hypersensitive patients for personalized strategy, Crit Rev Oncol Hematol, vol.93, issue.14, pp.188-195, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02148578

H. Schmidberger, R. M. Hermann, C. F. Hess, and G. Emons, Interactions between radiation and endocrine therapy in breast cancer, Endocr Relat Cancer, vol.10, pp.375-88, 2003.

R. A. Toillon, N. Magne, I. Laios, M. Lacroix, H. Duvillier et al., Interaction between estrogen receptor alpha, ionizing radiation and (anti-) estrogens in breast cancer cells, Breast Cancer Res Treat, vol.93, pp.207-222, 2005.

D. Azria, C. Larbouret, S. Cunat, M. Ozsahin, S. Gourgou et al., Letrozole sensitizes breast cancer cells to ionizing radiation, Breast Cancer Res, vol.7, pp.156-63, 2005.
URL : https://hal.archives-ouvertes.fr/inserm-00094862

C. K. Osborne, D. H. Boldt, G. M. Clark, and J. M. Trent, Effects of tamoxifen on human breast cancer cell cycle kinetics: accumulation of cells in early G1 phase, Cancer Res, vol.43, pp.3583-3588, 1983.

M. S. Anscher, T. Murase, D. M. Prescott, L. B. Marks, H. Reisenbichler et al., Changes in plasma TGF beta levels during pulmonary radiotherapy as a predictor of the risk of developing radiation pneumonitis, Int J Radiat Oncol Biol Phys, vol.30, pp.671-677, 1994.

A. A. Colletta, L. M. Wakefield, F. V. Howell, K. E. Van-roozendaal, D. Danielpour et al., Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts, Br J Cancer, vol.62, pp.405-414, 1990.

S. M. Bentzen, J. Z. Skoczylas, M. Overgaard, and J. Overgaard, Radiotherapy-related lung fibrosis enhanced by tamoxifen, J Natl Cancer Inst, vol.88, pp.918-940, 1996.

N. S. Bese, C. Umay, S. Yildirim, S. Ilvan, A. Dirican et al., The effects of tamoxifen on radiationinduced pulmonary fibrosis in Wistar albino rats: results of an experimental study, Breast, vol.15, pp.456-60, 2006.

D. Kim, A. S. Lee, Y. J. Jung, K. H. Yang, S. Lee et al., Tamoxifen ameliorates renal tubulointerstitial fibrosis by modulation of estrogen receptor alpha-mediated transforming growth factor-beta1/Smad signaling pathway, Nephrol Dial Transplant, vol.29, pp.3084-92, 2014.

D. Azria, O. Riou, F. Castan, T. D. Nguyen, K. Peignaux et al., Radiationinduced CD8 T-lymphocyte Apoptosis as a Predictor of Breast Fibrosis After Radiotherapy: Results of the Prospective Multicenter French Trial, EBioMedicine, vol.2, pp.1965-73, 2015.

D. Azria, S. Gourgou, W. J. Sozzi, A. Zouhair, R. O. Mirimanoff et al., Concomitant use of tamoxifen with radiotherapy enhances subcutaneous breast fibrosis in hypersensitive patients, Br J Cancer, vol.91, pp.1251-60, 2004.

M. J. Cecchini, E. Yu, K. Potvin, D. Souza, D. Lock et al., Concurrent or Sequential Hormonal and Radiation Therapy in Breast Cancer: A Literature Review, Cureus, vol.7, 2015.

P. H. Ahn, H. T. Vu, D. Lannin, E. Obedian, M. P. Digiovanna et al., Sequence of radiotherapy with tamoxifen in conservatively managed breast cancer does not affect local relapse rates, J Clin Oncol, vol.23, pp.17-23, 2005.

E. E. Harris, V. J. Christensen, W. T. Hwang, K. Fox, and L. J. Solin, Impact of concurrent versus sequential tamoxifen with radiation therapy in early-stage breast cancer patients undergoing breast conservation treatment, J Clin Oncol, vol.23, pp.11-17, 2005.

L. J. Pierce, L. F. Hutchins, S. R. Green, D. L. Lew, J. R. Gralow et al., Sequencing of tamoxifen and radiotherapy after breast-conserving surgery in early-stage breast cancer, J Clin Oncol, vol.23, pp.24-33, 2005.

V. Valakh, M. G. Trombetta, E. D. Werts, G. Labban, M. K. Khalid et al., Influence of concurrent anastrozole on acute and late side effects of whole breast radiotherapy, Am J Clin Oncol, vol.34, pp.245-253, 2011.

M. Ishitobi, M. Shiba, T. Nakayama, K. Motomura, H. Koyama et al., Treatment sequence of aromatase inhibitors and radiotherapy and long-term outcomes of breast cancer patients, Anticancer Res, vol.34, pp.4311-4315, 2014.

D. Azria, Y. Belkacemi, G. Romieu, S. Gourgou, M. Gutowski et al., Concurrent or sequential adjuvant letrozole and radiotherapy after conservative surgery for early-stage breast cancer (CO-HO-RT): a phase 2 randomised trial, Lancet Oncol, vol.11, issue.10, pp.70013-70022, 2010.

C. Bourgier, S. Kerns, S. Gourgou, C. Lemanski, M. Gutowski et al., Concurrent or sequential letrozole with adjuvant breast radiotherapy: final results of the CO-HO-RT phase II randomized trialdagger, Ann Oncol, vol.27, pp.474-80, 2016.

G. Yavas, C. Yavas, H. Acar, H. Toy, D. Yuce et al., Comparison of the effects of aromatase inhibitors and tamoxifen on radiation-induced lung toxicity: results of an experimental study, Support Care Cancer, vol.21, pp.811-818, 2013.

R. Tell, M. R. Edgren, A. Sverrisdottir, J. Castro, T. Fornander et al., Radiation-induced cell cycle response in lymphocytes is not related to clinical side-effects in breast cancer patients, Anticancer Res, vol.23, pp.3077-83, 2003.

S. H. Ryu, Y. H. Chung, J. K. Lee, J. A. Kim, J. W. Shin et al., Antifibrogenic effects of tamoxifen in a rat model of periportal hepatic fibrosis, Liver Int, vol.29, pp.308-322, 2009.

M. Ozsahin, N. E. Crompton, S. Gourgou, A. Kramar, L. Li et al., CD4 and CD8 T-lymphocyte apoptosis can predict radiationinduced late toxicity: a prospective study in 399 patients, Clin Cancer Res, vol.11, pp.7426-7459, 2005.